P16蛋白在宫颈癌和宫颈上皮内瘤变中的表达及临床意义  

The expression and clinical significance of p16 protein in cervical cancer and cervical intraepithelial neoplasia

作　　者：赵刚[1] 周梅[2] 赵峰[2] 李景英[2] 

机构地区：[1]新疆医科大学附属中医医院B超室 [2]新疆医科大学附属肿瘤医院病理科,新疆乌鲁木齐830000

出　　处：《新疆医科大学学报》2010年第2期166-168,共3页Journal of Xinjiang Medical University

摘　　要：目的研究P16蛋白在宫颈癌、癌前病变和宫颈炎中的表达,以寻求预测宫颈癌及宫颈癌前病变早期诊断的生物学标记。方法应用免疫组化技术检测23例宫颈癌、63例宫颈上皮内瘤变(CIN)和20例宫颈炎P16蛋白的表达,并进行分析比较。结果(1)P16蛋白在宫颈癌与CINⅠ级、CINⅢ级与CINⅠ级中的表达差异具有统计学意义(P<0.05);在宫颈癌与宫颈炎、CIN与宫颈炎中的表达差异也具有统计学意义(P<0.05);(2)随着宫颈病变程度加重,P16蛋白的表达强度和阳性表达率不断升高(P<0.001)。结论P16蛋白的表达与宫颈癌及CIN病变程度及其进展有关,P16蛋白有可能作为宫颈癌及其癌前病变早期诊断的生物学标记。Objective To discuss the expression of p16 protein in cervical cancer,cervical precancerosis and cervical inflammation,explore the biological marker of diagnosis early in cervical cancer and cervical precancerosis.Methods The expression of p16 protein in 23 cases of cervical cancer,63 cases of cervical intraepithelial neoplasia（CIN） and 20 cases cervical inflammation were detected by immunohistochemical staining,and to analyse and compare the results.Results（1）The positive rates of p16 protein in cervical cancer and CINⅠ,CINⅢ and CINⅠ showed significant difference（P〈0.05）;the positive rates of p16 protein in cervical cancer and cervical inflammation,CIN and cervical inflammation showed significant difference too（P〈0.05）;（2）With the development of cervical lesion,the expression intensity and the positive expression of p16 were elevated uncreasingly（P〈0.001）.Conclusion The expression of p16 is related to cervical cancer and the extent and development of CIN lesion,it is suggested that p16 protein expression may be taken as a biomarkers for early diagnosis of cervical cancer and CIN.

关 键 词：P16蛋白 宫颈癌 宫颈癌前病变 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤] R737.33[医药卫生—临床医学]