取代异噁唑甲酰基脲的合成及其抑菌活性  

Synthesis and antimicrmatic activities of substituted isoxazolyl acylureas derivatives

作　　者：季文文[1] 姜林[2] 藤信焕[1] 

机构地区：[1]山东农业大学植物保护学院,山东泰安271018 [2]山东农业大学化学与材料科学学院,山东泰安271018

出　　处：《化学试剂》2010年第1期63-65,93,共4页Chemical Reagents

摘　　要：以5-甲基-3-(取代)苯基-4-异噁唑甲酰胺及取代苯胺为起始原料,经两步反应合成了10种N-取代苯基-5-甲基-3-(取代)苯基-4-异噁唑甲酰基脲新化合物,其结构经1HNMR、IR和元素分析确证。初步测试了目标化合物对番茄灰霉病菌和小麦纹枯病菌的室内抑菌活性,结果表明,部分化合物对番茄灰霉病菌表现出较好的抑菌活性。Ten novel compounds of N-substituted phenyl-5-methyl-3-（substituted） phenyl-4-isoxazolyl acylureas derivatives were synthesized with 5-methyl-3-（substituted） phenyl-4-isoxazolyl acylamide and substituted anilines as starting materials,which were characterized by means of IR,1HNMR spectra and elemental analysis.Preliminary antibacterial experiments were tested,and the results indicated that some of the above compounds have good antibacterial activities.

关 键 词：异噁唑衍生物 酰基脲 合成 抑菌活性 

分 类 号：O621.2[理学—有机化学]