异噁唑的合成研究  

Synthesis of isoxazole

作　　者：蔡东[1] 商琳琳[1] 贾云宏[1] 邹军[2] 

机构地区：[1]辽宁医学院基础学院,辽宁锦州121001 [2]沈阳化工研究院,辽宁沈阳110021

出　　处：《化学试剂》2010年第1期94-96,共3页Chemical Reagents

摘　　要：以1,1,3,3-四乙氧基丙烷和盐酸羟胺为原料,水为溶剂,回流反应30 min,1,1,3,3-四乙氧基丙烷和盐酸羟胺的物质的量比为1.0∶1.05,得到异噁唑、乙醇、水的混合物,异噁唑收率可达99%。通过1HNMR对异噁唑进行了结构表征。同时研究了不同反应条件下所得产品混合物中异噁唑、乙醇、水的含量,为直接用此混合物制备3-乙氧基丙烯腈和3,3-二乙氧基丙腈提高了不同的原料选择。The mixture of isoxazole,ethanol,and water was obtained by using 1,1,3,3-tetraethoxypropane and hydroxylamine hydrochloride as raw materials,and water as solvent.The optimum reaction conditions were as follows：a reflux time of 30 min,a molar ratio of n（1,1,3,3-tetraethoxypropane）∶n（hydroxylamine hydrochloride）=1.0∶1.05.In this case,the yield of isoxazole was up to 99%.The structure of isoxazole was characterized by 1HNMR analysis,meantime,compositions of the final products（isoxazole,ethanol and water） were analysized under different reaction conditions,which could be used to prepare 3-ethoxyacrylonitrile and 3,3-diethoxypropionitrile.

关 键 词：1 1 3 3-四乙氧基丙烷 异噁唑 合成 3-乙氧基丙烯腈 3 3-二乙氧基丙腈 

分 类 号：TQ252[化学工程—有机化工]