调宁蛋白表达水平与慢性乙型肝炎患者肝脏微循环障碍的关系  

Relationship between the expression of calponin with liver microcirculatory disturbance in patients with chronic hepatitis B

作　　者：代雪枫[1] 严家春[1] 李峻峰[1] 徐长江[1] 袁苏娜[1] 

机构地区：[1]解放军第123医院肝病中心,安徽省蚌埠市233015

出　　处：《实用肝脏病杂志》2010年第2期89-92,共4页Journal of Practical Hepatology

摘　　要：目的探讨调宁蛋白(CaP)表达水平变化与慢性乙型肝炎(CHB)肝脏微循环障碍的关系。方法在200例CHB及10例肝组织正常的肝活检标本,采用免疫组化法检测CaP表达。结果在对照组,CaP仅在血管及胆管表达,肝实质细胞无表达;在CHB轻、中、重度组及肝硬化(LC)患者之间,随着肝窦及微血管病变由轻到重,CaP阳性及强阳性率逐渐升高,随肝窦扩张、血管改建、纤维化程度而加重,各组间存在显著性差异(P<0.01);在血管病变轻的CHB轻度组,CaP主要表达在炎症区及伴血管炎周围的肝细胞、内皮细胞、贮脂细胞,而在血管病变较重的CHB中度、CHB重度和LC组,CaP不仅在肝细胞弥漫性表达,在肝窦壁、毛细血管化区域、成肌纤维细胞及肌纤维束均有表达。结论CaP表达水平变化与CHB肝脏血液循环障碍有关。Objective To study the relationship between variation of calponin（CaP） expression and liver microcirculation disturbance of CHB.Method The liver biopsies samples from 200 patients with chronic hepatitis B（CHB） and 10 normal liver biopsies were stained for CaP expression by immunohistochemonical method.Results In control,CaP expression was showed in blood vessel and bile duct;In sinusoidal and microangiopathy mild（G1,G2） groups,CaP expression were showed dispersion or interrupt on hepatocyte,endotheliocyte and fat storing cell of domain of inflammation with vasculitis in hepatic tissue,and the positive was majority and a few showed negative and strong positive occupied 6%;But,in severe groups,not only CaP expression was showed diffuse by hepatocytes,but also there were all CaP expression in the liver sinusoidal walls and domain of capillarization and muscle fiber bundle.CaP expression ratio of strong positive was upgraded by degrees with sinusoidal expansion and vascular rebuilding or fibrosis.Between of the interclass was significantlly difference（P 0.01）.Conclusion The variation of CaP expression was related to abnormal microcirculation in livers of CHB.

关 键 词：慢性乙型肝炎 调宁蛋白 肝脏微循环障碍 

分 类 号：R512.62[医药卫生—内科学]