伽玛刀治疗恶性梗阻性黄疸近期疗效观察  

Short-term efficacy of gamma knife radiosurgery in the treatment of patients with malignant obstructive jaundice

作　　者：胡宗涛[1] 费振乐[1] 彭勇[1] 陈永超[1] 吕东来[1] 

机构地区：[1]合肥市解放军第105医院肿瘤中心,230031

出　　处：《实用肝脏病杂志》2010年第2期121-123,共3页Journal of Practical Hepatology

摘　　要：目的评价伽玛刀治疗恶性梗阻性黄疸的近期疗效。方法采用伽玛刀治疗恶性梗阻性黄疸患者20例。根据病变大小和部位选用不同大小的准直器,50%～70%等剂量曲线覆盖整个靶区,单次周边剂量给予3～5Gy,周边总剂量35～50Gy,分割8～12次,每周3～5次。结果血清胆红素从伽马刀治疗前的215.4±143.5μmol/L在治疗2周后降为98.4±54.5μmol/L(P<0.05);CR3例,PR14例,总有效率(CR+PR)为85%;治疗前疼痛强度数字评估法(NRS)为6.96±1.21,治疗后为2.06±1.07(P<0.01)。结论伽玛刀治疗恶性梗阻性黄疸安全有效,黄疸症状和疼痛明显缓解,提高了患者的生命质量。Objective To evaluate the short-term efficacy of gamma knife radiosurgery in the treatment of patients with malignant obstructive jaundice.Methods 20 patients with malignant obstructive jaundice were treated by gamma knife radiosurgery.According to the size and location of the tumors,different diameters of collimator helmets were used.The radiosurgery plan was designed to cover whole target area at isodose curves of 50% to 70% with a margin dose of 3 to 5 Gy each time and the total margin dose of 35 to 50Gy,which was carried out at a frequency of 3 to 5 times each week.Results The serum levels of total bilirubin decreased from 215.4±143.5μmol/L to 98.4±54.5μmol/L after two week treatment（P0.01）;CR was in 3 and PR in 14 patients with the effective rate of 85%;The pain intensity measured by numerial rating scale was 6.96 ±1.21 before the treatment,while it was 2.06±1.07 after the treatment.Conclusion Gamma knife radiosurgery is an effective and safe treatment in patients with malignant obstructive jaundice.

关 键 词：恶性梗阻性黄疸 全身伽玛刀 肿瘤转移 放射疗法 

分 类 号：R735[医药卫生—肿瘤]