抑郁症残留症状及对疾病结局影响  

The residual symptoms of depression and their effects on outcome of disease

作　　者：陈银娣[1] 汪作为[1] 张少平[1] 方芳[1] 黄乐萍[1] 肖春兰[1] 罗碧明[1] 蒋学萍[1] 

机构地区：[1]上海市虹口区精神卫生中心,200083

出　　处：《临床精神医学杂志》2010年第2期76-78,共3页Journal of Clinical Psychiatry

基　　金：上海市公共卫生优秀青年人才培养计划(08GWQ030);上海市卫生局青年科研课题(2008Y056);虹口区医学科研课题(虹卫0801-03)

摘　　要：目的:调查抑郁症残留症状及危险因素和其对疾病结局影响。方法:选择100例治疗12周以上抑郁症患者,评估人口社会学资料、抑郁症状、生活事件、应对方式、社会支持、生活质量和社会功能。结果:贝克抑郁自评问卷(BDI)≥5分和汉密顿抑郁量表17项(HAMD17)≥8分的患者比例分别为53%和49%;残留症状与负性生活事件(t=-4.90,P=0.00)、积极应对方式(t=8.22,P=0.00)、消极应对方式(t=-4.53,P=0.00)、社会支持(t=2.01,P=0.05)及家庭支持(t=1.97,P=0.05)明显有关;有残留症状者生活质量和社会功能显著差于无残留症状者(P<0.01)。结论:抑郁症患者残留症状发生率相当高,需要心理社会干预。Objective： To investigate the residual symptoms of depression and their effects on the outcome of disease. Method：100 patients with depression, who received treatments over 12 weeks,were evaluated the demographic data, depressive symptoms, life events, coping style, social support, life quality and social function. Results：The proportion of patients with Beck depression inventory（BDI） score ≥5 or Hamilton depression scale（ HAMDI7 ） score ≥8 were respectively 53% or 49%. Residual symptoms of depression were re- lated significantly to negative life events （ t = - 4. 90, P = 0.00 ）, positive coping style （ t = 8.22, P = 0. 00 ）, negative coping style （t = -4. 53, P = 0.00）, social support （t = 2. 01, P = 0.05 ） and family support （t = 1.97, P = 0.05 ）. The life quality and social function of depressive patients with residual symptoms were notably poorer than those without residual symptoms （ P 〈 0.01 ）. Conclusion： The prevalence rate of residual symptoms of depression is considerablely high and it is necessary to conduct psychosocial intervention.

关 键 词：抑郁症 残留症状 危险因素 疾病结局 

分 类 号：R749.4[医药卫生—神经病学与精神病学]