单相抑郁症患者颅脑CT双侧额叶形态学的研究  

Study on morphology of bi-frontal lobe in patients with unipolar depression

作　　者：文璐[1] 孙剑[2] 翟清[2] 周智[2] 徐乐平[2] 

机构地区：[1]江苏大学临床医学院,江苏镇江212013 [2]解放军第102医院

出　　处：《临床精神医学杂志》2010年第2期91-93,共3页Journal of Clinical Psychiatry

摘　　要：目的:探讨单相抑郁症患者颅脑CT双侧额叶形态学变化。方法:对80例单相抑郁症患者进行颅脑CT扫描,计算双侧额叶指数,并与80例正常人进行对照比较。结果:患者组的左额叶指数(24.92±2.64)比正常对照组(23.87±2.25)显著增大,(P<0.01),而右额叶指数差异无显著性(P>0.05)。患者组左额叶指数与年龄(Beta=0.357,P<0.01)、病程(Beta=0.289,P<0.01)呈正相关,右额叶指数与年龄(Beta=0.316,P<0.01)呈正相关,而与病程无显著相关性(P>0.05)。结论:与正常人相比,单相抑郁症患者左额叶萎缩,其萎缩程度与病程有关。Objective： To explore the morphological changes of hi-frontal tobe, s in patients with unipolar depression by cerebral CT. Method ： Eighty patients with unipolar depressive disorder and 80 normal controls were scanned by cerebral CT,and the hi-frontal index was compared. Results：Left frontal index of the patients （ 24.92 ±2.64 ） was significantly higher than that of normal controls （ 23.87 ±2.25 ） （ P 〈 0.01 ）, while there was no signficant difference in right frontal index between two groups. Left frontal index was positively associated with age （ beta = 0.357, P 〈 0. 01 ） and duration of depression （ beta=0. 289, P 〈 0.01 ）, and right frontal index was positively related to age（ beta =0. 316,P 〈0.01 ）,but not significantly related to duration of depression（ P 〉 0.05 ）. Conclusion：The atrophy of the left frontal lobe might present in unipolar depression, and the degree of atrophy might be associated with the duration of depression.

关 键 词：单相抑郁症 额叶 

分 类 号：R749.4[医药卫生—神经病学与精神病学]