碳核苷的合成及生物活性研究(英文)  

Synthesis and Biological Activities of C nucleosides

作　　者：孙德群[1,2] 邓金根[1,2] 马灵台 

机构地区：[1]中国科学院成都有机研究所 [2]北京医科大学药学院研究室

出　　处：《合成化学》1998年第4期404-407,共4页Chinese Journal of Synthetic Chemistry

摘　　要：通过呋喃汞盐与溴代木糖的偶合，合成５个新碳核苷；经过元素分析，１ＨＮＭＲ，１３ＣＮＭＲ，ＭＳ，ＩＲ确定了它们的结构；并检验了其中两个化合物对α－及β－硫代葡糖苷酶的抑制活性。Five new C nucleosides were first prepared by starting from the coupling between D bromidexylose and furan mercury chloride, and their structures were identified by elemental analysis, 1H NMR, 13 C NMR, MS and IR. The inhibitive activities of two C nucleosides on α and β D glucosidase have been measured.

关 键 词：碳核苷 合成 活性 硫代葡糖苷酶 抑制活性 

分 类 号：Q525.03[生物学—生物化学]