ILK、ER在子宫内膜癌组织中的表达及相关性分析  

The study of expression and correlation of ilk and estrogenreceptor(er) in endometrial carcinoma

作　　者：李春玲 刘春在 李胜水[3] 江泽[4] 许华[3] 张凤梅[3] 刘岩[3] 李双标[3] 

机构地区：[1]河北省沧州市妇幼保健院妇科,河北沧州061001 [2]河北省沧州南大港医院病理科,河北沧州061103 [3]河北省沧州中西医结合医院病理科,河北沧州061001 [4]河北省沧州市中心医院外科,河北沧州061001

出　　处：《中国当代医药》2010年第9期39-41,共3页China Modern Medicine

摘　　要：目的:探讨整合素连接激酶(ILK)、雌激素受体(ER)在子宫内膜癌组织中的表达及相关性。方法:应用免疫组化SP法,检测60例子宫内膜癌、34例癌旁组织和20例正常子宫内膜标本中ILK、ER蛋白的表达情况。结果:①ILK蛋白在子宫内膜癌组织的阳性表达率为65.0%,显著高于正常内膜组织(5.0%)及癌旁组织(8.8%)(P<0.001)。②ER在正常子宫内膜及癌旁组织中的阳性表达率分别为100.0%、94.1%,均高于其在子宫内膜癌组织中的表达(50.0%)(P<0.001)。③ILK随着晚临床分期、组织低分化、深肌层浸润及发生淋巴结转移表达增高(P<0.05),ER表达与组织学分级、肌层浸润程度有关(P<0.05)。④ILK与ER在子宫内膜癌组织中的表达呈负相关(r=0.314,P=0.014)。结论:ILK在子宫内膜癌的发生、发展过程中发挥着重要作用,ER随细胞恶变而发生改变。对ILK、ER表达水平的联合检测在子宫内膜癌的诊断、治疗及判断预后方面有一定的指导意义。Objective： To study the expression of ILK and estrogenreceptor（ER） in Endometrial carcinomas（EC）,and to evaluate itscorrelation with the clinicopathological features. Methods： Tissues from 60 EC,34 paracarcinoma and 20 norma1endometrium were analyzed for ILK and ER expression by immunohistochemical SP method. Results： The expression of ILK in EC, paracarcinoma and normal endometrium were 65.0%,8.8% and 5.0% respectively. The expression of ILK was significantly higher in EC than that in paracarcinoma and normal endometrium（P0.001）.The expression of ER in normal endomtrium and parac arcinoma was 100.0%,94.0%,which was significantly higher than that in EC（50.0%, P0.001）.ILK expression was associated with clinical stage,histological grade,myometrial invasion and lymph node metastasis（ P0.05）.ER expression was associated with histologic grade and myometrial invasion（P0.05）.Negative correlation between ILK and ER expression was found（r=0.314,P=0.014）. Conclusion： ILK plays an important role in the carcinogenesis and development of endometrial carcinoma.Combined analyses of the exression of ILK and ER are helpful in the diagnoses,treatment and prog nosis evaluation of EC.

关 键 词：子宫内膜癌 免疫组化 整合素连接激酶(ILK) 雌激素受体(ER) 

分 类 号：R737.33[医药卫生—肿瘤]