荧光法研究 Ge-132 对苯丙氨酸 Maillard 反应的抑制作用  

Fluorescence Spectrometric Study on the Suppression of Ge132 on Maillard Reaction of Phenylalanine

作　　者：陈继[1] 马根祥[1] 李晓晶[1] 张树功[1] 李德谦[1] 

机构地区：[1]中国科学院长春应用化学研究所稀土化学与物理开放实验室

出　　处：《应用化学》1998年第6期89-91,共3页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金

摘　　要：哺乳动物体内氨基酸及蛋白质的非酶糖化反应（Ｍａｉｌａｒｄ反应）与糖尿病及其并发症的关系已引起广泛关注［１］，β－羧乙基锗倍半氧化物（Ｇｅ－１３２）具有预防糖尿病和调节糖代谢的作用［２］，研究Ｇｅ－１３２对Ｍａｉｌａｒｄ反应的抑制作用对于开发防治糖尿病...It has been observed that em of phenylalanine and glycosylated phenylalanine in fluoresce spectra are 2810 nm and 440 nm, respectively, that permits to investigate the suppression of Ge132 on the Maillard reaction of phenylalanine without any interference. The result shows that the fluorescence intensity(FI) of glycosylated phenylalanine increases continuously with the decrease of FI of phenylalanine, and Ge132 exhibits a suppression on the Maillard reaction of phenylalanine up to 423%.

关 键 词：苯丙氨酸 MAILLARD反应 锗-132 糖尿病 

分 类 号：R977.15[医药卫生—药品]