动眼神经电生理学研究的动物模型建立  

The animal model of oculomotor nerves injury for electrophysiological research

作　　者：孟佑强[1] 朱宁喜[1] 王旭辉[1] 冯保会[1] 杨敏[1] 万亮[1] 李心远[1] 李世亭[1] 

机构地区：[1]上海交通大学医学院附属新华医院神经外科,200092

出　　处：《中华神经外科杂志》2010年第2期183-185,共3页Chinese Journal of Neurosurgery

基　　金：国家自然科学基金资助项目（30571907）;上海市科委基金项目（05QMH1409）

摘　　要：目的建立适用于动眼神经损伤后神经再生及功能修复电生理研究的动物模型。方法20只Beagle犬随机均分为单纯损伤组及损伤＋刺激组。行右侧动眼神经海绵窦后段压榨损伤、颅内动眼神经刺激电极植入及右侧下斜肌记录电极植入。结果实验手术均被所有实验犬耐受，下斜肌记录电极和颅内刺激电极成功植入，可用于记录运动单位电位（MUPs）及混合肌肉动作电位（CMAPs）。结论应用于动眼神经再生修复电生理研究的动物模型已经建立，此模型具有良好的可行性及可重复性。Objective To establish a feasible and reproducible dog model of oculomotor nerves injury, and to investigate the physiological electric for ocuolomotor nerves regeneration and recovery. Methods Experiment was carried out on 20 normal adult Beagle dogs. All Beagle dogs were distributed equally simplex crush injury and crush plus electrical stimulation groups randomly. Ophthalmic and intracranial operations in Beagle dogs comprised electrode implantation of the right inferior obliquus and simplex crush injury or crush plus electrode implantation of the right oculomotor nerve behind of cavernous sinus. Results All the procedures used in the study were well tolerated by Beagle canines. Electrode implantation of the right inferior obliquus and the right oculomotor nerve behind of cavernous sinus was successful. The compound muscle action potentials （CMAPs） and muscle units potentials （MUPs）were recorded successfully. Conclusion The animal models have been established to study the physiological electric for ocuolomotor nerves regeneration and recovery and have shown great reproductibility and feasibility.

关 键 词：动眼神经 电生理学 模型 动物 狗 

分 类 号：R-332[医药卫生]