声触诊组织量化和瞬时弹性成像技术诊断肝纤维化的初步研究  

A preliminary clinical study on two kinds of ultrasonic elastographic technique for diagnosis of hepatic fibrosis

作　　者：冯卉[1] 张新力[1] 李猛[1] 周艳贤[1] 陈敏[1] 陈霞[1] 董政[1] 

机构地区：[1]解放军第三零二医院特诊科,北京100139

出　　处：《中华超声影像学杂志》2010年第3期227-230,共4页Chinese Journal of Ultrasonography

摘　　要：目的探讨声触诊组织量化技术（virtualtouchquantification，VTQ）和瞬时弹性成像（fibroscan）技术无创评价肝纤维化的临床应用价值。方法对观察组102例和对照组78例研究对象采用VTQ技术和Fibroscan技术检测肝组织硬度，对比肝组织病理纤维化分级。结果VTQ技术和Fibroscan技术检测得到的肝组织硬度值与肝纤维化程度均存在相关性，相关系数分别为0．43309（PdO．0001）和0．35840（P〈（）．（）（】（）4）；以VTQ测值≥1．4m／s区分轻度与中重度肝纤维化，约登指数最大，敏感度和特异度分别为85．4％和64．7％；以Fibriscan^7．75kPa区分轻度与中重度肝纤维化，约登指数最大，敏感度和特异度分别为66．7％、67．2％。VTQ检测成功率观察组为100％（102／102），对照组为100％（78／78）；Fibroscan检测成功率观察组为88％（90／102），对照组为100％（78／78）。结论两种弹性成像技术在无创诊断肝纤维化方面均具有临床价值，与Fibroscan技术相比，VTQ技术敏感度较高，适用范围较大，操作简便，具有更广泛的应用前景。Objective To explore the clinical value of virtual touch quantification technique（VTQ） and fibroscan technique for the diagnosis of hepatic fibrosis. Methods A total of 102 patients with chronic liver disease and 78 normal individuals were enrolled in the study. They were all examined with VTQ and fibroscan technique. Pathological results were used as standard criterion. Results The liver tissue riqidity was associated with pathological results. The coefficient of relativity was 0. 43309 （VTQ） and 0. 35840 （Fibrosean）. ROC curve displayed that VTQ value of 1.4 m/s and fibroscan value of 7.75 kPa can be used to differential diagnose the low grade liver fibrosis and high-grade liver fibrosis. The probability of success was 100% （102/102） and 100% （78/78） by VTQ,but 88%（90/102） and 100%（78/78） by fibroscan technique. Conclusions VTQ and fibroscan technique are useful in the diagnosis of hepatic fibrosis. Compared with fibroscan technique, VTQ has more advantages in sensitivity practicability and convenience.

关 键 词：超声检查 弹性 肝硬化 

分 类 号：R575.2[医药卫生—消化系统]