定量胰岛素敏感检测指数对判断脑卒中患者预后的价值  

Value of quantitative insulin sensitivity check index on judging prognosis of patients with cerebral stroke

作　　者：袁慧琳[1] 张颖冬[2] 张宙[1] 

机构地区：[1]南京医科大学附属脑科医院ICU,210029 [2]南京医科大学附属脑科医院神经内科,210029

出　　处：《临床神经病学杂志》2010年第1期52-54,共3页Journal of Clinical Neurology

摘　　要：目的探讨定量胰岛素敏感检测指数(QUICKI)对判断脑卒中患者预后的价值。方法对67例脑卒中(伴糖尿病38例)患者的预后(发病1个月死亡或生存)、血糖及胰岛素水平进行观察,计算QUIC-KI;分析其血糖、胰岛素水平及QUICKI与预后的关系。结果本组患者中死亡37例,存活30例。死亡患者的血糖[(11.64±4.14)mmol/L]、胰岛素水平[(41.21±23.58)mU/L]明显高于存活患者[(8.41±2.66)mmol/L、(25.90±24.00)mU/L],而QUICKI(0.115±0.011)显著低于存活者(0.129±0.015)(P<0.05～0.01);伴有糖尿病的脑卒中患者中,死亡患者与存活患者的血糖、胰岛素水平差异无统计学意义;伴糖尿病的脑卒中患者中,QUICKI<0.1181者死亡危险性明显高于QUICKI≥0.1181者(OR=5.87,95%CI:1.50～22.93)。结论QUICKI值可作为脑卒中患者,尤其是伴糖尿病的脑卒中患者判断预后的指标。Objective To explore the value of quantitative insulin sensitivity check index（QUICKI）on judging the prognosis of the patients with cerebral stroke.Methods 67 patients with cerebral stroke（38 cases complicated diabetes mellitus）were observed their prognosis（death or survival after onset 1 month）and their blood glucose and insulin levels were detected to account QUICKI.The relationship between blood glucose,insulin,QUICKI and prognosis were analyzed.Results In the all patients,37 cases were death and other 30 cases were survival.Bloold glucose and insulin levels of death group [（11.64±4.14）mmol/L,（41.21±23.58）mU/L] were obviously higher than those in survivor group [（8.41±2.66）mmol/L,（25.90±24.00）mU/L],but QUICKI（0.115±0.011）was significantly lower than that in the survivor group（0.129±0.015）（P〈0.05-0.01）.There was no obvious difference of blood glucose and insulin levels between the death group and the survivor group in the patients complicated diabetes mellitus.QUICKI 〈0.1181 had higher dead risk than patients with QUICKI≥0.1181 in the patients complicated diabetes mellitus（OR=5.87,95%CI：1.50-22.93）.Conclusion QUICKI may be used to judge the prognosis of the stroke patients,especially the patients complicated diabetes mellitus.

关 键 词：定量胰岛素敏感检测指数 脑卒中 预后 

分 类 号：R743.3[医药卫生—神经病学与精神病学]