癫痫脑损伤早期标志物的研究进展  

The Study of Early Markers on Epilepsy in Brain Injury

作　　者：杭妍[1] 张晖[2] 

机构地区：[1]内蒙古科技大学包头医学院,内蒙古包头014040 [2]包头市中心医院神经内科,内蒙古包头014040

出　　处：《医学综述》2010年第8期1190-1192,共3页Medical Recapitulate

摘　　要：癫痫发作可引起脑损伤,早期诊断及正确评估癫痫发作后脑细胞损伤的严重程度具有十分重要的意义。因此,寻找既敏感又特异的脑损伤生化指标,是目前学者们研究的焦点。现从S100B、神经元特异性烯醇化酶、髓鞘碱性蛋白、与溶血磷脂酸极性相似磷脂即酸性磷脂酸可能分别反映胶质细胞、神经元、神经髓鞘膜结构损伤、细胞膜磷脂裂解这几方面来阐述目前对癫痫引起脑损伤的早期标志物的研究进展情况。Epileptic seizures could result in brain damages.It was very important to make the early diagnosis and correct assessment of the severity of brain cell injuries after the epileptic seizures.Therefore,the researches focused on seeking the sensitive and specific biochemical indicators for brain damage.S100B,neuron-specific enolase,myelin basic protein and acidic phospholipid,similar to the polarity of lysophosphatidic acid,reflected the damage of glial cells,neurons,nerve myelin membrane and the lysis of membrane phospholipid,respectively.This review would describe the progress of these markers for early brain injury from these aspects.

关 键 词：癫痫 脑损伤 S100B 神经元特异性烯醇化酶 髓鞘碱性蛋白 酸性磷脂酸 

分 类 号：R742.1[医药卫生—神经病学与精神病学]