药物缓释材料的合成与性能  

Synthesis and Properties of Thermosensitive Material Used for Controlled Releasing of Medicine

作　　者：唐明义[1] 耿奎士[1] 巩运兰[1] 牛月兰 方静[1] 丁宏远[1] 王凤玲[1] 

机构地区：[1]天津商学院食品系,300400

出　　处：《合成树脂及塑料》1998年第4期22-25,共4页China Synthetic Resin and Plastics

基　　金：天津市自然科学基金

摘　　要：研究了聚氨酯/聚醚半互穿网络聚合物的合成、溶胀行为和释放性能,特别是疏水组成、线型聚醚结构和温度对网络的溶胀平衡和溶胀动力学的影响。同时还测量了大分子肝素在填充时的分配系数和释放速度,并对肝素从溶胀的互穿网络聚合物中释放的机理进行了讨论。This paper studied synthesis, swelling behaviour and release properties of PU/PEG semi - IPNs. It was found that hydrophobic component and structure of the linear polyether exerted influences upon the swelling equilibrium and deswelling kinetics of the networks. Partition coefficient and release speed of macromolecular heparin was also measured as function of temperature and network composition. The release mechanism of the heparin from the swollen semi - IPN was discussed.

关 键 词：制药 高聚物 药物 缓释材料 性能 

分 类 号：TQ460.4[化学工程—制药化工]