奥曲肽对胰腺炎相关性腹水所致肠损伤的疗效  

Curative effect of octreotide in the treatment of the intestine harm induced by pancreatitis associated ascetic fluid

作　　者：程若川[1] 方向[2] 赵海剑[1] 刁畅[1] 张建明[1] 

机构地区：[1]昆明医学院第一附属医院普通外科,650032 [2]四川省德阳市人民医院普外科

出　　处：《中华实验外科杂志》2010年第1期21-22,I0001,共3页Chinese Journal of Experimental Surgery

摘　　要：目的 观察胰腺炎相关性腹水（PAAF）对大鼠肠的损伤作用及奥曲肽对该损伤的疗效.方法 将48只SD大鼠随机分为空白对照组（A组）、模型对照组（B组）和奥曲肽治疗组（C组）,B组、C组腹腔内注射PAAF,C组用奥曲肽治疗,测定血清内毒素（LPS）和肿瘤坏死因子（TNF）-α;测定小肠组织的ATP酶和TNF-α;观察肠黏膜的病理变化.结果 B组与A组比较,除ATP酶活性显著下降（P〈0.05）外,上述指标均显著增高（P〈0.05;）C组与B组比较,除ATP酶活性较模型对照组显著增高（P〈0.05）外,上述指标均较之明显下降（P〈0.05）.结论 奥曲肽能够减轻PAAF诱导的大鼠肠损伤.Objective To investigate the curative effect of octyeotide in the treatment of the intes tine harm induced by pancreatitis associated ascetic fluid （PAAF） in rats. Methods Forty-eight healthy Sprague-Dawwley （SD） rats were randomly divided into three groups：blank group （A） ,model group （B） and octreotide treatment group （C）. PAAF was intraperitoneally injected in groups B and C,and octreotide was given in group C. The levels of serum lipopolysaccharides （LPS） and tumor necrosis factor a （TNF-α） were determined, and those of ATP enzyme and TNF-α were measured in intestinal tissues. The pathological changes of intestinal mucosa were observed. Results Except that the activity of ATP was decreased （P 〈 0.05） ,the indexes above were all increased （P〈0.05） in group A as compared with group B （P〈0.05）. Except that the activity of ATP enzyme was greatly increased （P 〈0.05） ,all the other indexes were obviously de creased in group C as compared with group B （P 〈0.05）. Conclusion Octreotide can alleviate the the intes tine harm induced by PAAF.

关 键 词：胰腺炎 腹水 肠黏膜 内毒素 奥曲肽 

分 类 号：R576[医药卫生—消化系统]