基于三维重建技术及有限元分析的骨密度测量  

Measurement of bone density based on three-dimensional reconstruction and finite element analysis

作　　者：张国栋[1] 陶圣祥[2] 毛文玉[3] 陈建桥[3] 栾夏刚[2] 郑晓晖 廖维靖[1] 

机构地区：[1]武汉大学中南医院康复医学科,湖北省武汉市430071 [2]武汉大学中南医院骨科,湖北省武汉市430071 [3]华中科技大学力学系,湖北省武汉市430074 [4]武装警察部队福建总队医院骨科,福建省福州市350025

出　　处：《中国组织工程研究与临床康复》2010年第9期1539-1544,共6页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：背景:为减少有限元分析的运算量,使之更具有临床实用性,前期试验对赋予材料属性进行了探讨,论证了赋予骨骼10种材料属性可以达到有限元分析的要求,同时发现通过有限元分析的方式,可以实现骨密度值的求解。目的:探讨基于三维重建技术及有限元分析测量骨密度的方法,对骨骼有限元分析的一般过程进行一定规范。方法:选用11侧股骨上段标本,对照组直接测量标本的质量;试验组将11侧标本进行高速CT薄层扫描,在Mimics10.0中进行三维重建,在Ansys中进行体网格划分,在Mimics中赋予10,100,400种材料属性,输出至Ansys计算骨骼中每一种材料属性的体单元体积,根据CT扫描灰度值与骨密度的经验公式,计算标本质量及密度,进行统计学处理。结果与结论:骨密度单因素方差分析结果显示,对照组与赋予10,100,400种材料属性各试验组差异均无显著性意义(P均>0.28),试验组各组别之间差异均无显著性意义(P均>0.8)。结果提示,该试验方法可定量测量骨骼质量、密度及骨密质和骨松质的比例,赋予骨骼10种材料属性即可达到测量要求,试验结果可为骨质疏松症的骨密度与有限元分析的统一作初步准备。BACKGROUND：To decrease operation amount of finite element analysis and increase its clinical practice,previous studies explored the material properties and 10 kinds of material attributes were assigned,which met the requirements of finite element analysis.Moreover,it can be used to calculate bone density.OBJECTIVE：To explore a method for measurement of bone density based on three-dimensional reconstruction and finite element analysis.METHODS：A total of 11 specimens of femoral superior segment were selected.The mass of control group was firstly measured.The experimental groups were treated with thin-slice high resolution CT scan and three-dimensional reconstruction in Mimics 10.0,volume meshing in Ansys,assigned with 10,100 and 400 kinds of material attributes Mimics,exported to Ansys to calculat the volumes of the block elements of every types of material attributes.The mass and the density of the specimens was harvested according to the empirical formula concerning the gray value and the bone density.All results were treated with one-way ANOVA.RESULTS AND CONCLUSION：One-way ANOVA showed that there were no significant differences between control group and experimental groups assigned with 10,100 and 400 kinds of material attributes（P 0.28）,and there were no significantly among the experimental groups（P 0.8）.Results show that the method was able to measure the mass and the density of bone quantitatively,as well as the proportion between compact bone and cancellous bone;to assign 10 kinds of material attributes to three-dimensional model of femur could match the needs for measurements.The results can be used as an initial preparation for the unification of bone density and finite element analysis for osteoporosis.

关 键 词：骨密度 三维重建 有限元 骨质疏松症 数字化骨科技术 

分 类 号：R772.2[医药卫生—眼科]