无创电阻抗胃动力检测与评价  

Noninvasive gastric motility measurement and evaluation by bioimpedance

作　　者：任超世[1] 李章勇[1] 王伟[1] 赵舒[2,3] 邓娟[2,3] 

机构地区：[1]重庆邮电大学生物信息学院,重庆市400065 [2]中国医学科学院 [3]北京协和医学院生物医学工程研究所,天津市300192

出　　处：《中国组织工程研究与临床康复》2010年第9期1653-1657,共5页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：国家自然科学基金项目资助(60471041;60901045)课题名称分别为采用生物阻抗无创提取胃动力信息与评价方法研究;及胃动力三维信息检测与电-机耦合传导机制评价方法研究~~

摘　　要：背景:采用生物阻抗方法,可无创提取与胃动力学状况相对应的生理、病理信息,获取胃的收缩、蠕动、传导及排空过程信息,实现胃动力功能的检测与评价。但阻抗法用于消化过程的较早研究工作多集中在胃排空方面,直接提取胃运动信息用于胃动力检测与评价的较少。目的:从电-机复合机制的高度认识胃动力,建立一种无创、方便的阻抗胃动力检测方法。方法:在总结阻抗胃动力信号特征的基础上,介绍了阻抗胃动力检测方法,开展了用于液体胃排空测量、餐前后胃动力对照、不同时段胃动力对照、药物影响等基础实验,并验证了在功能性消化不良患者胃动力检测和胃炎患者胃动力评价等方面的初步应用。结果及结论:采用生物阻抗方法,依据胃组织和胃内食物的电特性及其在消化过程中的变化规律,可提取与胃动力学状况相对应的生理、病理信息,分析胃的收缩、蠕动、传导及排空过程,实现胃动力功能的无创检测与胃运动状况的评价。BACKGROUND：Bioimpedance method can be used to extract physiology and pathology information relative to the gastric motility states,to investigate the courses of contraction,peristalsis,transmission and emptying of the stomach,to measure and evaluate gastric motility function.However,early studies mainly focused on the emptying of the stomach,and few studies on evaluation of gastric motility by extracting gastric motility information.OBJECTIVE：To understand the gastric motility from electricity-mechanism composite concept and to establish a noninvasive,convenience measurement method of gastric motility impedance.METHODS：Based on the characters of gastric motility impedance signal,a measurement method of impedance gastric motility is introduced.Some foundation experiments about the gastric emptying measurement,the gastric motility compare between fasting and repast,the gastric motility comparison of healthy volunteers during different periods and some medicine effects on gastric motility have carried out.The gastric motility measurement of the patients with functional dyspepsia and gastric motility evaluation for the patients with erosive gastritis had been reported.RESULTS AND CONCLUSION：Using electrical bioimpedance method,according to the electrical property of the stomach tissue or the food in stomach and the change rules of the property,the physiology and pathology information relative to the gastric motility states can be extracted,the courses of contraction,peristalsis,transmission and emptying of the stomach can be investigated and noninvasive measure and evaluation of gastric motility function can be realized.

关 键 词：生物电阻抗 胃动力 电-机复合机制 功能性消化不良 胃炎 数字化医学 

分 类 号：R772.2[医药卫生—眼科]