功能性消化不良患儿多导胃电与胃排空的关系研究  

Relationship between dectrogastrogram and gastric emptying in children with functional dyspepsia

作　　者：徐彰[1] 胡丹元[2] 蒋晓燕[1] 潘彤彤[1] 贺孝良[3] 徐辉[1] 

机构地区：[1]温州医学院附属第二医院育英儿童医院儿童消化科,325027 [2]温州医学院附属第二医院育英儿童医院新生儿科,325027 [3]温州医学院附属第二医院育英儿童医院呼吸科,325027

出　　处：《中华儿科杂志》2010年第4期249-253,共5页Chinese Journal of Pediatrics

基　　金：温州市科技局资助项目（Y2006A037）

摘　　要：目的探讨功能性消化不良（FD）患儿的胃电图异常与胃排空的相关性。方法使用Polygraf ID四导胃电分析系统和核素法固体胃排空测定51例FD患儿和25例健康体检儿童的胃电活动和胃排空情况。结果①FD组与对照组相比，正常慢波百分比（N％）明显低于对照组（P〈0．01）；FD组患儿有较高的胃电异常发生率，主要表现为餐前餐后混合性胃电节律紊乱，共32例，占62．7％。②FD组与对照组相比，4个导联餐后／餐前功率比差异有统计学意义（P〈0．05），显示FD组餐后主功率不增加。③FD组患儿餐前主频不稳定系数，餐前与餐后主功率不稳定系数增高；FD组患儿餐前、餐后慢波耦联率（％）分别为26．95±13．69，26．93±12．63，对照组为69．02±5．15，70．18±4．68，FD组慢波耦联率低于对照组（P〈0．01）。④FD组患儿胃排空延迟占23．5％，经Logistic多因素相关分析胃排空延迟与餐前、餐后慢波耦联率存在负相关（偏回归系数分别为-0．513，-0．296）。结论FD患儿有较高的胃电异常发生率，主要表现为胃电节律紊乱和餐后主功率不增加，餐前主频不稳定系数，餐前与餐后主功率不稳定系数增高，慢波耦联率降低；胃排空延迟与慢波耦联率存在负相关。提示胃电异常在FD的发病中有一定意义。Objective To investigate the correlations between electrogastrogram （EGG） and gastric emptying （GE） in children with functional dyspepsia （FD）. Methods A total of 51 children with FD and 25 healthy children as control were enrolled into this study. Polygraph ID 4-channel EGG analysis system was used for EGG recording and gastric emptying of solids was studied by using a standardized egg meal labeled with 99mTechnetium sulfur colloid for each subject. Results （ 1 ） Compared with the control group, the percentage of normal slow wave （ N% ） in the FD group was significantly lower than that of the control group （P 〈0. 01 ）. Children with FD had higher rates of abnormal EGG, in which 32 cases showed mixed dysrhythmia preprandial and postprandial recordings （62. 7% ）. （2） The two groups had significant difference in ratio of the percentage of preprandial dominant power （DP） to postprandial DP （P 〈 0. 05 ）, it showed that the postprandial DP of the FD group did not increase. （3） The postprandial dominant power instability coefficient （DPIC） as well as preprandial DPIC and dominant frequency instability coefficient （DFIC） in the FD group were increased. The coupling of the slow wave of preprandial and postprandial EGG in the FD group （26.95 ± 13.69, 26. 93 ±12. 63 respectively） significantly decreased as compared with those in the control group （69.02 ±5. 15, 70. 18 ±4.68, P 〈0.01）. （4） The rate of delayed gastric emptying in the FD group was 23.5%. The results of multivariate Logistic regression analysis showed that there was a significant negative correlation between the delayed gastric emptying and the coupling of the slow wave（partial regression coefficient = -0. 513, -0. 296 respectively）. Conclusions Patients with FD had more abnormal findings in EGG than the control group did, and there was a significant negative correlation between the delayed gastric emptying and the coupled response of the slow wave. The abnormal gastric electrical ac

关 键 词：消化不良 胃电描记术 胃排空 

分 类 号：R57[医药卫生—消化系统]