血清胆碱酯酶与肝硬化Child-Pugh分级的关系研究  

Studies on Relationship between Cholinesterase in Serum and Child-Pugh Classification in Hepatic Cirrhosis

作　　者：朱为伟[1] 王炳芳[2] 戴娜[2] 张明[2] 王庆华[2] 

机构地区：[1]江苏大学临床医学院,江苏镇江212000 [2]昆山市第一人民医院消化科

出　　处：《中国误诊学杂志》2010年第11期2521-2522,共2页Chinese Journal of Misdiagnostics

摘　　要：目的:探讨血清胆碱酯酶(ChE)活性与肝硬化Child-Pugh分级之间的关系。方法:测定58例肝硬化患者和25例健康人肝功能指标(包括白蛋白、前白蛋白、总胆红素、未结合胆红素)及血清ChE活性,并按Child-Pugh分级进行比较。结果:肝硬化组的ChE活性较对照组显著降低,按Child-Pugh分级,肝硬化组A级ChE活性与对照组,B级与A级,C级与B级之间差异均有统计学意义(P<0.01),依次降低。结论:血清ChE活性可作为判断肝硬化严重程度的有效指标,对病情的诊断和预后有重要的指导价值。Objective：To study the relationship between the activity of serum cholinesterase （ChE） and Child- Pugh classification in hepatic cirrhosis. Methods： 58 serum samples of patients with hepatic cirrhosis and 25 serum samples of the healthy were detected for hepatic functional indexes： serum albumin, prealbumin, total bilirubin, unconjugated bilirubin and ChE, and the patients classified according to the Child-Pugh score were included in the study. Results：The activity of ChE remarkablely declined in hepatic cirrhotic patients. According to the Child-Pugh classification, the ChE in different groups varied obviously. Conclusions：the activity of ChE in serum can be regarded as an effective marker to the extent of hepatic cirrhosis , which has the important guiding value on diagnosis and prognostic evaluation of hepatic cirrhosis.

关 键 词：胆碱酯酶类/血液 肝硬化/病理学 

分 类 号：R575.2[医药卫生—消化系统]