肺癌患者化疗前后血清TGF-α、TGF-β_1和VEGF测定的临床意义  

Clinical Significance of Determination of Changes of Serum TGF-α,TGF-β_1 and VEGF Levels After Chemotherapy in Patients with Lung Cancer

作　　者：喻永龙 朱永东[1] 朱西平[1] 杨成喜[2] 

机构地区：[1]安徽省宁国市人民医院肿瘤科,242300 [2]江苏省连云港市第一人民医院肿瘤科,222002

出　　处：《放射免疫学杂志》2010年第2期140-142,共3页Journal of Radioimmanology

摘　　要：目的:探讨肺癌患者化疗前后血清TGF-α、TGF-β1和VEGF水平的变化及临床意义。方法:分别应用放射免疫分析和酶联法对33例肺癌患者进行了化疗前后血清TGF-α、TGF-β1和VEGF测定,并与35名正常健康人作比较。结果:在化疗前血清TGF-α、TGF-β1和VEGF水平均非常显著的高于正常人组(P<0.01),经化疗后三个月与正常人组比较仍有显著性差异(P<0.05)。结论:检测肺癌患者化疗前后血清TGF-α、TGF-β1和VEGF水平的变化与肿瘤的发生、发展密切相关。Objective To explore the clinical significance of changes of serum TGF-α,TGF-β1 and VEGF levels after chemotherapy in patients with lung cancer. Methods Serum TGF-α,TGF-β1 （with RIA） and VEGF （with ELISA） contents were measured in 33 patients with lung cancer both before and after chemotherapy as well as in 35 controls. Results Before chemotherapy,serum TGF-α,TGF-β1 and VEGF levels were significantly higher （P0.01） in patients with lung cancer. After chemotherapy for 3 months,the serum TGF-α,TGF-β1 and VEGF levels dorpped markedly but still remained significantly higher （P0.05） than those in controls. Conclusion Serum TGF-α,TGF-β1 and VEGF levels were related to the development of tumor in patients with lung cancer.

关 键 词：肺癌 转化生长因子-Α 转化生长因子-Β1 血管内皮生长因子 

分 类 号：R735.7[医药卫生—肿瘤]