直肠癌根治术中影响肠腔肿瘤细胞脱落的因素分析  

CMultivariate Statistical Analysis：Significant Factors Causing Free Malignant Cells in Rectum During Radical Resection of Rectal Cancer

作　　者：刘战丛[1] 庞志刚[1] LIU Zhan-cong,PANG Zhi-gang （Department of General Surgery, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014,China）

机构地区：[1]郑州大学第二附属医院普通外科,河南郑州450014

出　　处：《医学信息》2010年第5期1320-1321,共2页Journal of Medical Information

摘　　要：目的 探讨直肠癌根治术中各临床病理特征、手术时间等相关因素对肠腔内肿瘤细胞脱落的影响。方法对我科2007年7月至2009年7月期间诊断为直肠癌并行根治手术的68倒患者行前瞻性研究，术中在离断肿瘤下端肠管前行肠腔内灌洗，收集灌洗液送病理科．送检标本中的癌细胞。统计检测结果。结果送检标本中，阳性标本共有30例，阴性标本38例。对可能影响检出结果的各因素行单因素统计分析，结果患者的年龄、肿瘤大小、TNM分期、手术时间差异有统计学意义（P〈0．05）。结论直肠癌根治术中必须常规行肠腔内灌洗，特别是肿瘤TNM分期晚、瘤体大及手术时间长的病例，更需重视肿瘤细胞脱落导致术后局部复发的风险。Objective To analyze the risk factors inducing tumor cells extoliating during radical resection ot rectal cancer. Methods Sixty-elght patients who were diagnosed as rectal cancer from July 2007 to July 2009 and given radical operations were assigned prospectively in this study. Before cutting the rectal stump below the tumor,saline was instilled into rectum to irrigate the stump. Collected irrigating fluids were sent to pathology laboratory.The results of examines were collected and statistical analysis. Results Exfoliated malignant cells were found in 30 samples. By univariate analysis,the statistically significant factors defining a high risk of exfoliating were age, tumor size,TNM stage,operation time （P〈0.05）. Conclusion Irrigating the rectal stump before cutting down the tumor is essential to avoid local recurrence.

关 键 词：直肠癌根治术 肠腔灌洗 脱落肿瘤细胞 

分 类 号：R735.37[医药卫生—肿瘤;医药卫生—临床医学]