喹硫平合并帕罗西汀治疗强迫症临床研究  

A Clinical Study of the Efficacy of Quetiapine Combined with Paroxetine in the Treatment of Obsession

作　　者：张明松[1] 张慧芳[1] 郭平[1] 

机构地区：[1]河南省驻马店市精神病医院,463000

出　　处：《慢性病学杂志》2010年第4期299-300,共2页Chronic Pathematology Journal

摘　　要：目的:探讨喹硫平合并帕罗西汀治疗强迫症的临床疗效和安全性。方法:将47例强迫症患者随机分为帕罗西汀组,喹硫平合并帕罗西汀组,随访8周。采用Yale-Brown强迫症量表(Y-Bocs),汉密尔顿焦虑量表(HAMA)和副反应量表(TESS)评定疗效和不良反应。结果:基线时两组间Y-BOCSHAMA评分相似。随访第8周时喹硫平合并帕罗西汀组Y-BOCS评分(12.4±4.7)低于帕罗西汀组(16.1±3.9,t=2.576,P=0.037),HAMA评分(6.9±3.8)也低于帕罗西汀组(10.1±3.6,t=2.236,P=0.017)。结论:喹硫平合并帕罗西汀用于强迫症的治疗有明确的疗效和安全性。Objective：To evaluate the clinical efficiency and safety of quetiapine combined with paroxetine in treating obsession.Methods：47 patients with obsession were randomly divided into paroxetine group and quetiapine with paroxetine group,and then follow up for 8 weeks.Yale-Brown Obsessive-compulsive disorder scale（Y-BOCS）,Hamilton anxiety scale（HAMA）and treatment emergent symptom scale（TESS）were used to evaluate the efficiency and adverse effects.Results：The scores of Y-BOCS and HAMA at the base time were Similarly.Yet the Y-BOCS score of the quetiapine with paroxetine group（12.4±4.7）was lower than it of the paroxetine group（16.1 ±3.9,t=2.576,P=0.03）.The HAMA score of the quetiapine with paroxetine group（6.9±3.8）was lower than the it of the paroxetine group（10.1±3.6,t=2.236,P=0.017）.Conclusion：Quetiapine combined with paroxetine have exacta efficiency and safety in treating Obsession.

关 键 词：抗精神病药/治疗应用 帕罗西汀/治疗应用 药物疗法 联合 强迫性人格障碍/药物疗法 人类 

分 类 号：R749.75[医药卫生—神经病学与精神病学]