鼻咽癌放疗中CEP与NCT靶区照射剂量的比较分析  

Deviations of planning target dose in radiotherapy for nasopharyngeal carcinoma

作　　者：王玉龙[1] 冯炎[2] 潘自强[2] 林原[2] 李龙根[2] 

机构地区：[1]太原市中心医院肿瘤科,太原030009 [2]复旦大学医学院肿瘤医院放射治疗科

出　　处：《山西医科大学学报》2010年第4期312-315,共4页Journal of Shanxi Medical University

摘　　要：目的通过对鼻咽癌放疗中普通常规模拟定位计划靶区临床处方剂量(DCEP,target)与非定位CT治疗计划优化靶区参考剂量(DNCT,target)的比较分析,了解非定位CT-TPS(治疗计划系统)在临床放疗中的应用价值。方法对33例接受^(60)Co外照射治疗鼻咽癌患者的78个鼻咽双侧野及12个鼻前野的普通常规临床模拟定位计划方案(CEP)与非定位CT-TPS优化方案(NCT)进行比较分析,各项参数组间均值差异用配对t检验,并对比值频数分布直方图进行GaussianCurve性偏度与峰度检验及D检验。结果鼻咽双侧野与鼻前野剂量偏差频数分布直方图结果显示,二者拟合曲线均呈正态分布,误差分别为-4.01%±4.06%和-1.01%±2.93%,有统计学差异(P<0.05)。结论非定位CT-TPS在治疗计划优化选择中发挥重要作用,但也要谨防其对临床的误导。Objective To evaluate the value of the NSIC-CT-TPS（NCT,nonsimulation irradiation condition,computer tomogram,treatment planning system）in radiotherapy for nasopharyngeal carcinoma（NPC）by comparing and analyzing the clinical expectation prescription（CEP）dose of treatment planning system（TPS）and the reference dose of the computer tomogram（CT）of non-simulation irradiation condition（NSIC-CT）.Methods The difference of the target depth（dcm）,tissue-maximum ratio（TMR）,target dose（DcGy）and biologically effective dose（BEDcGy）of the lateral facial field（LFF,n=78 fields）and the anterior facial field（AFF,n=12 fields）in NPC patients with AECL-780 C cobalt-60 radiotherapy were recorded and compared by NCT and CEP.Using the histogram of frequent distribution,according to the norm of CEP and ±5%（International Communittee on Radiation Units,ICRU）,the differences（d,TMR,D,BED）of CEP and NCT were analyzed,and the frequent conditions were determined with Gaussian-test and D-test.Results Gaussian-test of both frequent curves indicated normal distribution.The deviations between DNCT,target and DCEP,target for LFF（n=78 fields）and AFF（n=12 fields）were-4.01%±4.06%（P0.05）and-1.01%±2.93%（P0.05）,respectively.Conclusion NSIC-CT TPS is one of the most important measures to appraise the optimum plan for NPC in radiotherapy,but it should be alerted to mislead the clinical use.

关 键 词：鼻咽癌 放射治疗 优化选择 质量保证 

分 类 号：R739.6[医药卫生—肿瘤]