律复康胶囊对哇巴因致豚鼠心律失常模型的作用  

Study of Lfukang Capsules on experimental arrhythmia induced by Ouabain in cavia cobayas

作　　者：韩丽华[1] 王振涛[1] 陈舒茵[2] 申洪超[2] 黎瑞汝[2] 梁生旺[2] 

机构地区：[1]河南省中医院,河南郑州450008 [2]广东药学院中药学院,广东广州510006

出　　处：《中国医药导报》2010年第12期36-37,共2页China Medical Herald

基　　金：河南省科技创新人才计划项目(0621002700)

摘　　要：目的:观察律复康胶囊对哇巴因致豚鼠心律失常模型的对抗作用,为临床用药提供依据。方法:取实验豚鼠50只,均分为模型对照组(等容量蒸馏水)、阳性对照组(4.185g/kg)、律复康胶囊小剂量组(1.539g生药/kg)、中剂量组(3.078g生药/kg)和大剂量组(6.156g生药/kg),各组豚鼠按剂量连续给药3d,末次药后30min,建立哇巴因致豚鼠心律失常模型,用Medlab生物信号采集处理系统记录豚鼠肢体电极检测标准Ⅱ导心电图,分别记录出现室性早搏、心室颤动和心脏停搏时哇巴因的用量。结果:律复康胶囊各剂量组豚鼠出现早搏、室颤和停博时所需哇巴因的剂量显著提高,与模型对照组比较,差异有统计学意义(P<0.01或P<0.05)。结论:律复康胶囊能够显著增加诱发豚鼠出现心律失常时哇巴因的剂量,说明律复康胶囊对哇巴因诱发的心律失常有一定的对抗作用。Objective：To observe the anti-arrhythmic effects of Lfukang Capsules on the experimental arrhythmic models induced by Ouabain in cavia cobayas,and provide accordance for clinical medication. Methods：50 cavia cobayas were divided into model control group （distilled water of the same volume）,positive control group （4.185 g/kg）,low dosage group （1.539 g crude drug/kg）,middle dosage group （3.078 g crude drug/kg） and high dosage group （6.156 g crude drug/ kg） of Lfukang Capsules respectively. All the dosage groups were given successive medication for 3 days,arrhythmic models induced by Ouabain for 30 min after the last dosage in cavia cobaya. The signal of Medlab biology processing system was used to record standard Ⅱ electrocardiogram of cavia cobaya that interpolation limb electrode of detection,and the threshold doses of Ouabain of ventricular premature beat （VP）,ventricular fibrillation （VF） and asystole were recorded. Results：All the dosage groups of Lfukang Capsules significantly increased the threshold doses of VP,VF and asystole of arrhythmic models of cavia cobaya （P0.01 or P0.05）. Conclusion：Lfukang Capsules can obvioushy increase the dosage of Ouabain inducing arrhythmia in cavia cobayas,and has anti-arrhythmic effects on the experimental arrhythmic models induced by Ouabain.

关 键 词：律复康 心律失常 哇巴因 豚鼠 

分 类 号：R-332[医药卫生]