联合检测血清黏附分子及C反应蛋白在急性胰腺炎中的应用  

Combined detection of serum cICAM-1 and CRP in acute pancreatitis

作　　者：徐德亮[1] 孟钰[1] 李金来[1] 

机构地区：[1]山东省枣庄市立医院消化内科,277102

出　　处：《国际消化病杂志》2010年第2期115-118,共4页International Journal of Digestive Diseases

摘　　要：目的探讨联合检测血清细胞间黏附分子(cICAM-1)和C反应蛋白(CRP)对急性胰腺炎(AP)诊断、分型和预后评估的临床意义。方法对60例AP患者,其中轻症型(MAP)36例,重症型(SAP)24例,和20例其他急性腹痛患者,连续6d采用ELISA法测定其cICAM-1水平变化。并用比浊法测定入院后第1、3、7和14天血清CRP水平。结果SAP组患者cICAM-1水平显著高于MAP组和其他急性腹痛组(P<0.05),而MAP组与其他急性腹痛组患者间cICAM-1水平比较无统计学意义(P>0.05)。MAP患者cICAM-1浓度-时间曲线呈下降型,SAP患者浓度时间曲线呈逐渐上升或降而复升型。AP患者入院第1周CRP水平显著高于其他急性腹痛组(P<0.05)。SAP组患者CRP水平显著高于MAP组(P>0.05)。结论联合检测cICAM-1和CRP有助于更快速诊断AP和有效判断预后。Objective To study on the combined detection of serum circulating intercellular adhesion molecule-1 （clCAM-1） and C reactive protein（CRP ）in diagnosis and prognosis of acute pancreatitis （AP）. Methods From April 2006 to December 2008, retrospective study was done on 60 patients：Thirty six patients with mild acute pancreatitis （MAP）,and 24 with severe acute pancreatitis （SAP）. The level of serum cICAM 1 in the patients were detected serially over a period of 6 days by enzyme linked immunosorbent assay（ELISA）,and CRP was detected on days 1, 3, 7 and 14 after admission in 6（1 patients with AP, and 20 patients with other acute abdominal pain were controlled. Results The level of serum clCAM-1 was significantly higher in patients with SAP than patients with MAP or other acute abdominal pain （P〈0. 05）. The level of cICAM 1 between MAP and other acute abdominal pain was not significant （P〉0. 05）. Decreasing and peak clCAM-1 levels were found in the patients with MAP. clCAM-1 level with an increasing or relapsing pattern was observed in the patients with SAP. The level of CRP was significantly higher in patients with AP on the first week after admission than patients with other acute abdominal pain （P〈 0.05）. The level was also higher in SAP than that in MAP （ P〈0. 05）. In addition, the highest level of CRP was present on day 3 after admission of patients with AP, and CRP maintaining higher levels revealed the poor prognosis. Conclusion The combined detection of serum cICAM-1 and CRP is helpful to diagnosis, curative effect observation and prognosis in AP.

关 键 词：急性胰腺炎 血清细胞间黏附分子 C反应蛋白 

分 类 号：R576[医药卫生—消化系统] R446.6[医药卫生—内科学]