42例髓母细胞瘤的临床分析  

Clinical analysis of 42 patients with cerebellar medulloblastoma

作　　者：罗文广[1] 张红雁[1] 马军[1] 赵于飞[1] 

机构地区：[1]安徽省立医院,230001

出　　处：《中国医学创新》2010年第11期17-19,共3页Medical Innovation of China

摘　　要：目的回顾性分析42例髓母细胞瘤的临床资料,观察全脑全脊髓放射治疗疗效及预后因素。方法 1996年3月至2004年8月,42例术后病理证实的髓母细胞瘤患者在我科接受放疗,先予全脑全脊髓照射30～36 Gy,然后缩野至后颅窝局部加量20～25 Gy。采用Kaplan-Meier法计算生存率,生存差异比较采用Log-rank检验。结果全组患者5年生存率为54.8%,手术全切与次全切除患者5年生存率分别为60.6%、33.3%(P=0.041),手术和放疗间隔时间≤28 d与>28 d患者5年生存率分别为69.6%、36.8%(P=0.029)。结论髓母细胞瘤术后全脑全脊髓放疗能取得较好疗效,手术切除程度及术后放疗开始时间与预后相关。Objective Through analyze the clinical data of 42 patients with cerebellar medullohlastoma retrospectively, we observed its curative effect and prognostic factors by radiotherapy. Methods From March 1996 to August 2004 ,42 patients with medulloblastoma that comfirmed by surgery and pathology received radiotherapy. The patients were irradiated with 30 - 36 Gy delivered to the whole eraniospinal axis followed by a 20 - 25 Gy boost to the posterior fossa. Kaplan - Meier method was used to analyze the survival rate, Log - rank was used to compared the difference between groups. Results The 5 - year survival rate of all patients were 54. 8%. The 5 - year survival rate was 60. 6% for the patients received total resection of tumour,while it was 33.3% for which received subtotal resection（ P =0. 041 ）. Patients whose radiation treatment had been started within 28 days after operation showed a better survival than those beyond the 28th day, with 5 - year overall survival of 69. 6% and 36. 8% （ P = 0. 029 ）. Conclusion Satisfactory efficacy can be achieved by craniospinal axis irradiation for patients with cerebellar medulloblastoma. The extent of resection and the interval between surgery and radiation were prognostic factors of medulloblastoma.

关 键 词：髓母细胞瘤 全脑全脊髓放射治疗 预后因素 

分 类 号：R739.4[医药卫生—肿瘤]