Smac/DIABLO在上皮性卵巢癌组织中的表达及临床意义  

Expression of Smac/DIABLO in Epithelial Ovarian Carcinoma and Its Clinical Significance

作　　者：徐欣然[1] 张虹[1] 

机构地区：[1]天津市中心妇产科医院肿瘤科,300052

出　　处：《国际妇产科学杂志》2010年第2期136-138,F0003,共4页Journal of International Obstetrics and Gynecology

基　　金：天津市卫生局局级课题(07KY04)

摘　　要：目的:探讨Smac/DIABLO在上皮性卵巢癌组织中的表达及临床意义。方法:采用免疫组化技术分别检测30例正常卵巢、30例良性上皮性卵巢肿瘤、30例交界性上皮性卵巢肿瘤及60例上皮性卵巢癌的组织中Smac/DIABLO蛋白的表达水平。结果:在上皮性卵巢癌中Smac/DIABLO阳性表达率为41.67%(25/60),低于良性上皮性卵巢肿瘤(83.33%,25/30)和正常卵巢组织(90.00%,27/30),差异有统计学意义(χ2=14.06,P<0.0083;χ2=19.15,P<0.0083)。且随组织学分级和临床分期增高,卵巢癌组织中Smac/DIABLO表达逐渐降低(F=7.23,P<0.05;F=4.48,P<0.05)。Smac/DIABLO阴性表达者生存期短于阳性表达者。结论:Smac/DIABLO在上皮性卵巢癌组织中阴性表达与上皮性卵巢癌不良预后相关。Objective：To investigate the expression of Smac/DIABLO in epithelial ovarian carcinomas and its clinical significance.Methods：The expression of Smac/DIABLO proteins was detected with immunohistochemistry.Results：The positive expression rate of Smac/DIABLO in ovarian carcinomas was significantly lower than that in benign ovarian tumors and normal ovaries（χ2=14.06,P 0.008 3;χ2=19.15,P 0.008 3）.In ovarian carcinomas,the expression of Smac/DIABLO was significantly decreased during progression from early to advanced tumour clinical stages and histological grade（F=7.23,P 0.05;F=4.48,P 0.05）.There was relationship between the low expression of Smac/DIABLO and poor prognosis of epithelial ovarian carcinomas.Conclusions：There was low expression of Smac/DIABLO in epithelial ovarian carcinomas,Smac/DIABLO was related to the poor prognosis of ovarian carcinomas.

关 键 词：上皮性卵巢癌 SMAC/DIABLO 细胞凋亡 免疫组化 

分 类 号：R737.31[医药卫生—肿瘤]