那他霉素在真菌性角膜溃疡愈合中的治疗作用  

Observation of therapeutical effect of natamyc in fungal corneal ulcer

作　　者：王冬梅[1] 陈光胜[1] 黄明汉[2] 

机构地区：[1]中国广西壮族自治区柳州市红十字会医院眼科,柳州市眼科医院,545000 [2]广西医科大学第一附属医院眼科,中国广西壮族自治区南宁市530000

出　　处：《国际眼科杂志》2010年第4期744-745,共2页International Eye Science

摘　　要：目的:通过对那他霉素和氟康唑治疗真菌性角膜溃疡的对照研究,探讨那他霉素在真菌性角膜溃疡愈合中的治疗作用。方法:对84例确诊真菌性角膜溃疡患者随机分为甲、乙两组,每组42例,分别用那他霉素眼液及氟康唑眼液进行治疗。结果:那他霉素组治愈21例,有效34例,无效8例,有效率81%;氟康唑组治愈11例,有效29例,无效13例,有效率69%;两组有效率比较,差异无统计学意义(χ2=1.587,P>0.05);两组治愈率比较,差异有统计学意义(χ2=5.048,P<0.05),那他霉素组治愈率(50%)明显高于氟康唑组(26%);那他霉素组有效治疗时间(16.7±7.68d),明显低于氟康唑组(28.6±7.3d),两组差异显著,有统计学意义(t=7.94,P<0.01)。结论:那他霉素对真菌性角膜溃疡具有较好的治疗作用,优于氟康唑。值得临床推广使用。AIM： To evaluate the efficacy of natamyc in curing fungal corneal ulcer by a case-control study of natamyc and fluconazole. METHODS： Eighty-four cases with fungal corneal ulcer were divided into two groups with 42 cases in each group. Natamyc and fluconazole were used for each group respectively. RESULTS： Twenty-one cases were cured, 34 cases were effectively and 8 cases were ineffective, the effective rate was 81% in natamyc group.In fluconazole group, the corresponding number of cases was 11,29,13 respectively, and the effectively and ineffectively,effective rate was 69%. There was no significant difference between the two groups in effective rate （χ^2=1.587,P0.05）;there was a significant difference between the two groups in cure rate （χ^2=5.048,P0.05）,and also a significant difference between the two groups in average period of therapy which was 16.7±7.68 days in natamyc group and 28.6±7.3 days in fluconazole group （t=7.94, P0.01）. CONCLUSION： Natamyc is more effective than fluconazole in treatment of fungal corneal ulcer, which can be generalized in clinic.

关 键 词：那他霉素 治疗作用 真菌性角膜溃疡 

分 类 号：R772.21[医药卫生—眼科]