VEGFR-3与早期舌癌隐匿性淋巴转移的关系  

Relationship between Vascular Endothelial Growth Factor Receptor-3 and Occult Metastasis in Early-Stage Tongue Cancer

作　　者：李慧文[1] 黄鹏[2] 

机构地区：[1]天津医科大学口腔医院,300070 [2]天津工业大学

出　　处：《天津医药》2010年第3期207-208,257,共3页Tianjin Medical Journal

摘　　要：目的：检测血管内皮生长因子受体-3（VEGFR-3）在早期舌癌中的表达,探索其与隐匿性淋巴转移的关系。方法：免疫组化SP法检测62例早期舌癌中VEGFR-3的表达及定位,并分析其与早期肿瘤大小、隐匿性淋巴转移及组织分化程度的关系。结果：癌实质未见VEGFR-3表达,VEGFR-3阳性淋巴管主要表达在癌周,隐匿性淋巴转移组癌周VEGFR-3表达尤为丰富,管腔密集,管径扩张。病理分级Ⅱ~Ⅲ级患者VEGFR-3的表达显著高于Ⅰ级者（t=4.77,P〈0.05）,隐匿性淋巴转移患者VEGFR-3的表达显著高于无淋巴转移患者（t=6.33,P〈0.05）,不同年龄（≤65岁和〉65岁）、性别（男/女）及肿瘤大小（≤2cm和2~4cm）患者的VEGFR-3的表达差异无统计学意义（P〉0.05）。结论：VEGFR-3可作为早期舌癌术前衡量隐匿性淋巴转移的有用指标。Objective： To detect the expression of vascular endothelial growth factor receptor-3 （VEGFR-3） in earlystage tongue cancer and the relationship with occult metastasis thereof. Methods： The expression of VEGFR-3 was examined in paraffin-embedded specimens from 62 patients with early-stage tongue cancer by immunohistochemical staining. The relationship was analyzed between the expression of VEGFR-3 and size, occult metastasis and differentiation of early-stage tongue cancer. Results： The positive expression of VEGFR-3 mainly located in the lymphatic endothelial cells of peritumoral areas and negative expression in tumor area. The higher expression of VEGFR-3 was found in patients with occult metastasis. The expression of VEGFR-3 was significantly higher in patients of Ⅱ-Ⅲ grade than that of patients inⅠgrade carcinoma （t = 4.77, P 0.05）. The expression of VEGFR-3 was higher in patients with occult metastasis than that in patients with negative lymph node （t = 6.33, P 0.05）. But there were no significant correlation between the expression of VEGFR-3 and the age, gender and size of tumor in patients. Conclusion： The value of VEGFR-3 can be a useful indicator to evaluate the occult metastasis of early-stage tongue cancer.

关 键 词：血管内皮生长因子受体3 舌肿瘤 癌 淋巴转移 免疫组织化学 

分 类 号：R739.86[医药卫生—肿瘤]