磁共振成像对帕金森病患者黑质致密带的研究  

A Magnetic Resonance Imaging Study of the Pars Compacta of Substantia Nigra in Parkinson's Disease

作　　者：赵丹[1] 毛传万[2] 黄建河[2] 唐兰英[1] 戴美芬[1] 胡丹[1] 张雄[1] 

机构地区：[1]温州医学院附属第二医院神经内科,325027 [2]温州医学院附属第二医院影像科,325027

出　　处：《中国临床神经科学》2010年第2期130-134,共5页Chinese Journal of Clinical Neurosciences

基　　金：浙江省科技厅钱江人才(编号:2008R10040);浙江省卫生厅(编号:2006A097);温州市科技局(编号:H20060030)

摘　　要：目的:探讨磁共振成像(MRI)辅助诊断帕金森病(PD)的价值。方法:对30例PD患者、28例健康对照者进行MRI检查,通过T2加权成像(T2WI)测量黑质致密带(SNc)的宽度,计算分析其与中脑直径的比值和病情的关系;通过灰质抑制成像(GMSI)、白质抑制成像(WMSI)对SNc信号进行观察,在其减影像上进行相对信号值的测量。结果:在T2WI上,PD组SNc的测量宽度(1.173±0.908)mm较对照组(1.722±0.540)mm明显变窄(P=0.027),PD组SNc宽度与中脑直径比值(0.029±0.023)较对照组(0.044±0.014)下降(P=0.017),SNc宽度与病情程度间无显著差异(F=1.484,P=0.236),两者间无明显相关性(r=0.149,P=0.542);在GMSI、WMSI上,PD患者SNc信号丢失以外侧部明显,在其减影图像上,SNc外侧部信号与内侧部信号比值有显著差异(P=0.003 4)。结论:MRI(T2WI、GMSI、WMSI)对辅助诊断PD有应用价值。Aim： To explore the value of magnetic resonance imaging（MR/） in auxiliarily diagnosing of Parkinson＇ s disease（PD）. Methods： 30 patients with PD and 28 aged-matched healthy controls were imaged by MRI, the width of pars compacta of substantia nigra （SNc）, the ratios of the width to mesencephalon diameter and the relations between the width and disease severity were computered and analyzed on T2- weighted imaging （T2WI）. The signal of SNc were observed on grey matter suppressed imaging（GMSI）, white matter suppressed imaging（WMSI）, and the relative signal value were measured on their subtraction imagings. Results： Compared with controls, the width of PD patients were narrowing（P=0.027）, the ratios of the width to mesencephalon diameter of PD patients were decreased（P=0.017）, there were no significant differences between the SNc and disease severity（F=l.484, P=0.236）, and the correlation between them were not predominant（r=0.149, P=0.542）. The signals of SNc of PD patients were lost, especially in the lateral parts on the GMSI and WMSI, the ratios between the lateral parts and medial parts had significant differences（P= 0.003 4）. Conclusion： MR/ （T2WI, GMSI, WMSI） may have application value for diagnosing Parkinson＇ s disease.

关 键 词：帕金森病 磁共振成像 黑质致密带 灰质抑制成像 白质抑制成像 

分 类 号：R742.5[医药卫生—神经病学与精神病学]