拉莫三嗪对癫癎患者生活质量影响的研究  

Effect of Lamotrigine on Quality of Life in Patients with Newly Diagnosed Epilepsy

作　　者：虞培敏[1] 丁玎[1] 朱国行[1] 吴洵昳[1] 于欢[1] 卫国华[2] 丁美萍[3] 狄晴[4] 吴立文[5] 王玉平[6] 孙红斌[7] 王学峰[8] 廖卫平[9] 周列民[10] 肖波[11] 朱遂强[12] 黄希顺[13] 迟兆富[14] 洪震[1] 

机构地区：[1]复旦大学附属华山医院神经内科,200040 [2]上海交通大学医学院附属瑞金医院,200025 [3]浙江大学医学院第二附属医院,310009 [4]南京脑科医院,210029 [5]北京协和医院,100730 [6]首都医科大学附属宣武医院,100053 [7]四川省人民医院,610072 [8]重庆医科大学附属第一医院,400016 [9]广州医学院附属第二医院,510260 [10]中山大学附属第一医院,510080 [11]中南大学湘雅医院,410008 [12]华中科技大学附属同济医院,400030 [13]郑州大学医学院附属第一医院,450052 [14]山东大学齐鲁医院,250012

出　　处：《中国临床神经科学》2010年第2期167-172,共6页Chinese Journal of Clinical Neurosciences

基　　金：课题研究资金由葛兰素史克公司提供(编号:LAM111576)

摘　　要：目的:评价拉莫三嗪对癫癎患者生活质量的影响。方法:采用多中心、前瞻性的研究方法,对新诊断癫癎患者应用拉莫三嗪治疗,并在基线期及用药6个月后,采用QOLIE-31、MOS SF-36量表、数字符号转换测验、HAMD抑郁量表和女性专用调查问卷对患者进行生活质量评价。结果:共纳入新诊断癫癎患者282例。MOS SF-36量表的8个项目得分在用药后均有显著提高(P<0.01);QOLIE-31问卷中"对癫癎的担心"、"情绪"、"活力"、"认知"、"药物不良反应"、"社会功能"及"总体自身健康评价"项目得分在用药后均有显著提高(P<0.01)。用药后,患者Hamilton抑郁量表平均3.65分,显著低于基线期6.42分(P<0.01);数字符号转换测验得分在用药后与基线期比较有显著提高(P<0.01)。结论:拉莫三嗪初始单药治疗能在一定程度上改善新诊断癫癎患者的生活质量。Aim： To assess the effect of lamotrigine on quality of life after six-month treatment in patients with newly diagnosed epilepsy. Methods： Totally 282 patients with newly diagnosed epilepsy from fourteen study sites in China were enrolled in the study. All the patients started to take lamotrigine as antiepileptic therapy from baseline. The initial dosage and titration procedure were based on regularly clinical practice. Quality of life and cognitive function assessments were taken at the baseline and after 6-month treatment. Quality of life assessment instruments included Short Form 36 （SF-36） health survey, QOLIE-31, Hamilton Depression Rating Scale （HAMD）, Digital symbol test and questionnaire for woman patients. ResuLts： 282 patients completed the final visit, 162 male and 120 female. 109（46.2%） were seizure free after six-month treatment. All domains of SF-36 scale and seven domains of QOLIE-31 were significantly improved after treatment, except for ＂general quality of life＂ in QOLIE-31. The average score of HAM-D was 3.65 at the end point, which was significantly higher than the baseline score 6.42 （P〈0.01）. The score of digital symbol test also indicated a significant progress （P〈0.01）. Conclusion： Lamotrigine had a favorable effect of efficacy, cognitive function and quality of life in patients with newly diagnosed epilepsy.

关 键 词：癫痫 拉莫三嗪 生活质量 

分 类 号：R742.1[医药卫生—神经病学与精神病学]