RegIV expression showing specificity to gastrointestinal tract and its potential role in diagnosing digestive tract neuroendocrine tumor  

作　　者：Feng-ying LI Xiao-bin REN En-ping XU Qiong HUANG Hong-qiang SHENG Bing-jian LV Mao-de LAI 

机构地区：[1]Department of Pathology, School of Medicine, Zhejiang University, Hangzhou 310058, China [2]Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China [3]Department of Epidemiology and Biostatistics, School of Medicine, Zhejiang University, Hangzhou 310058, China [4]Anatomical and Cellular Pathology, Women 's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2010年第4期258-266,共9页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：Project supported by the International Cooperation Program (No. 2007C24009);the Major Project of Natural Foundation of Zhejiang Province (No. D2080011);the Major Special Project of Science and Technology Found of Zhejiang Province (No. 2007C3020);the Natural Science Foundation of Zhejiang Province, China (No. Y2090152)

摘　　要：Regenerating gene IV （RegIV）, a member of the regenerating gene family discovered in 2001, has been found to be involved in malignancy in several different organs including the stomach, colorectum, pancreas and prostate, but the overall expression profile of RegIV has not been reported. To learn more about RegIV, we evaluated its distribution by immunohistochemistry （IHC） in a total of 360 samples including 24 types of normal tissue, 40 benign and malignant lesions, and 18 neuroendocrine tumors. We found that in normal tissues, in addition to its relative specificity for the gastrointestinal tract, RegIV was detected in the adrenal gland and mammary gland. Among all the malignancies of various histological types under evaluation, RegIV was found mostly in adenocarcinomas. Studies on additional sets of colorectal tumor samples showed that RegIV expression was predominant in colorectal adenoma （87.5%） and peritumoral tissue （100%） but not in cancer tissue （30.8%）. Among neuroendocrine tumors, ReglV had a relatively restricted expression to those of digestive system.Regenerating gene IV (RegIV),a member of the regenerating gene family discovered in 2001,has been found to be involved in malignancy in several different organs including the stomach,colorectum,pancreas and prostate,but the overall expression profile of RegIV has not been reported. To learn more about RegIV,we evaluated its distribution by immunohistochemistry (IHC) in a total of 360 samples including 24 types of normal tissue,40 benign and malignant lesions,and 18 neuroendocrine tumors. We found that in normal tissues,in addition to its relative specificity for the gastrointestinal tract,RegIV was detected in the adrenal gland and mammary gland. Among all the malignancies of various histological types under evaluation,RegIV was found mostly in adenocarcinomas. Studies on additional sets of colorectal tumor samples showed that RegIV expression was predominant in colorectal adenoma (87.5%) and peritumoral tissue (100%) but not in cancer tissue (30.8%). Among neuroendocrine tumors,RegIV had a relatively restricted expression to those of digestive system.

关 键 词：Colorectal cancer Expression profile Neuroendocrine tumor Regenerating gene IV （RegIV） 

分 类 号：R735[医药卫生—肿瘤]