骨转换标志物在非小细胞肺癌骨转移临床应用中价值的研究  

Research on the clinical application value of bone turnover markers in bone metastases from nonsmall cell lung cancer

作　　者：王智煜[1,2] 杨晨[1] 高云潮[3] 沈赞[1] 杨玉妹[1] 赵晖[1] 姚阳[1] 

机构地区：[1]上海交通大学医学院附属上海市第六人民医院肿瘤内科,上海200233 [2]上海交通大学医学院研究生院,上海200235 [3]上海交通大学医学院附属上海市第六人民医院核医学科,上海200233

出　　处：《中国癌症杂志》2010年第3期202-206,共5页China Oncology

基　　金：上海申康医院发展中心(项目编号:SHDC12007304);上海市浦江人才发展计划(项目编号:08PJ14073)

摘　　要：背景与目的:骨转移导致骨质破坏,可引起骨转换标志物(bone turnover markers)水平的改变;因此,本研究旨在探讨骨转换标志物在非小细胞肺癌(non-small cell lung cancer,NSCLC)骨转移诊断及病情评价方面的应用价值。方法:定量检测76例NSCLC骨转移患者血清中碱性磷酸酶(alkaline phosphatase,AKP)、β-Ⅰ型胶原羧基端肽(β-C-terminal telopeptide of type Ⅰ collagen,β-CTx)、骨钙素(osteocalcin,OST)和骨特异性碱性磷酸酶(bone-specific alkaline phosphatase,BALP)水平,并与44例健康人群进行对照。结果:骨转移组患者血清中AKP、β-CTx和BALP水平均明显高于正常对照组。各骨转换标志物之间有很好的相关性,BALP和OST的表达水平与骨转移程度呈正相关性。β-CTx表达水平较高和BALP表达水平较低的患者发生病理性骨折可能性增加。结论:骨代谢标志物在NSCLC骨转移患者诊断及病情判断方面有重要的参考价值,在临床上有广泛的应用前景。Background and purpose：Bone metastases leads to the destruction of bones by changing the level of bone turnover markers.The purpose of this study was to assess the clinical application value of bone turnover markers in bone metastases for non-small cell lung cancer,which included the diagnosis and spread behavior of bone metastases.Methods：AKP,β-CTx,OST and BALP were measured in 76 NSCLC with bone metastases patients and 44 normal people.Results：The level of AKP,β-CTx and BALP in patients with bone metastasis was significantly higher than in the subjects without bone metastases.There were significant correlations among the bone turnover markers.The levels of BALP and OST were significantly positively correlated with the extent of bone metastasis.Patients with high-levels of CTx and low-levels of BALP had a higher risk of pathologic fracture.Conclusion：In patients with bone metastases from NSCLC,bone turnover markers can help make diagnoses and evaluate severity of disease.It potentially has a wide range of uses in clinical practice.

关 键 词：非小细胞肺癌 骨转移 骨转换标志物 

分 类 号：R734.2[医药卫生—肿瘤]