阿立哌唑与碳酸锂对躁狂发作的疗效及认知功能的对照研究  

A control study of Aripiprazole and Lithium carbonats on efficacy and quality of manice pisode

作　　者：孙群星[1] 刘勇[1] 朱玉星[1] 龙金亮[1] 

机构地区：[1]河南省驻马店市精神病院,463000

出　　处：《中国实用医药》2010年第12期19-21,共3页China Practical Medicine

摘　　要：目的比较阿立哌唑与碳酸锂治疗对躁狂发作患者的疗效及对认知功能的影响。方法采用入院顺序分层随机法,将120例躁狂发作患者平均分为研究组(阿立哌唑)和对照组(碳酸锂),在治疗前,治疗后4、8、12周末各做一次韦氏成人智力量表、韦氏记忆量表、铁槽铁钉测验、手指敲击试验、动作功能测验、手功能协调测验、连线测验a和b、威斯康星卡片分类测验(WCST)及言语流利性测验等10项神经心理测查及Bech-Rafaelsen躁狂量表(BRMS)和临床疗效总评量表(CGI)及副反应表(TESS)评定疗效和不良反应,韦氏记忆量表(WMS)评定治疗前后患者认知功能的改变。结果治疗12周后,两组BRMS总分在治疗后与治疗前比较有统计学差异(P<0.01),及各因子分比治疗前明显降低(P<0.01)。研究组有效率96.7%,显效率70.0%;对照组有效率95.0%,显效率66.7%。两组间疗效无统计学差异(P>0.05),碳酸锂组不良反应比阿立哌唑组多。经12周治疗,从各项神经心理测查均值的变化趋势看,研究组与对照组从8周开始有逐渐好转的趋势,与治疗前相比,敲击测验、动作能力测验、手功能协调测验、WCST完成类别数等认知功能均显著改善,且研究组好于对照组(P<0.05)。结论阿立哌唑治疗躁狂发作疗效好,不良反应小,对认知功能的改善更彻底。Objective To observe the efficacy and quality of Aripiprazole and lithium carbonas in the treatment of mannic episode.MethodsBeing used the random control study,120 manic episode patients were divided into study group（Aripiprazole）and control group（lithium carbonas）.Before and after the treatment,Weschler abult intelligence scale,Weschler memory scale,grooved pegboard test,finger tapping test,motor function test,hand coordination test,trail making test A and B,wisconsin card sort test,and verbal fluency test,Effects and side effects assessed witn BRMS,CGI and TESS were done on the 4th,8th and 12th weekends respectively.Results12 weeks after treatment,the total BRMS scores of the two groups were significantlt different（P0.01）,and each factors scores decreased than those before treatment（P0.01）.Effective rate of study group was 96.7%,good rate was 70.0%,while in the control they were 95.0%and 66.7%respectively.The effective rates of the two groups did not have significant difference and the control group had more adverses than the study group.Through 12 weeks-treatment,according to the average value trend of the nerve and mental examinatios,study and control goups were improved gradually from the beginning of the 8th week.The cognition detected by pound test,action ability test,hand function moderate test,WCST completion category number etc,was improved obviously caompared with that of before treatment.The study group was better than the control group（P0.05）.ConclusionThe Aripiprazole to treat the manice pisode disease has accurately curative effect,high safety ant completed improvement of the cognition function.

关 键 词：躁狂发作 阿立哌唑 碳酸锂 疗效 认知功能 

分 类 号：R749.4[医药卫生—神经病学与精神病学]