组织多肽特异性抗原检测在非小细胞肺癌中的临床意义  

The clinical significance of TPS detection in non-small cell lung cancer

作　　者：魏民[1] 

机构地区：[1]濮阳市油田总医院病理科,河南濮阳457001

出　　处：《中国实验诊断学》2010年第4期538-540,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨组织多肽特异性抗原(TPS)在非小细胞肺癌患者血清中的表达水平及其临床应用价值。方法采用酶联免疫吸附法测定48例非小细胞肺癌患者、30例肺部良性疾病患者和40例健康受检者的血清TPS浓度水平。结果非小细胞肺癌患者血清TPS水平明显高于肺部良性疾病患者和正常对照组(P<0.05)。不同性别、年龄、病理类型、有无纵隔淋巴结转移的非小细胞肺癌患者中血清TPS水平之间比较,差异无统计学意义(P>0.05)。临床分期为Ⅲ-Ⅳ期的患者的TPS浓度明显高于Ⅰ-Ⅱ期病人,差异有统计学意义(P<0.05),在经过手术和化疗后血清TPS水平明显下降(P<0.05)。结论血清TPS水平检测对非小细胞肺癌的早期诊断、病情判断和治疗疗效评价等具有重要意义。Objective To investigate the levels and clinical value of tissue polypeptide specific antigen （TPS） in serum of patients with non-small cell hmg cancer（NSCLC） .Methods The levels of serum TPS were measured by enzyme linked immtmosorbent assay（ELISA） in 48 cases of NSCLC,30 cases of hmg benign diseases and 40 cases of healthy control.Results The levels of serum TPS in NSCLC group were significantly higher than those in the lung benign diseases group and healthy control group （ P 〈 0.05）. The TPS levels were analogous between different gender, age and pathological type group and there were no significant difference （ P 〉 0.05）. The TPS levels of TNM III- IV stage NSCLC patients was much higher than those of TNM I - II stage, and there was significant difference （P 〈 0.05）. After the NSCLC patients got operation or chemotherapy, the levels of serum TPS go down significantly （ P 〈 0.05）. Conclusion The levels of serum TPS is a very useful and valuable tumor marker for early diagnosing and judgement of disease and treatment reaction.

关 键 词：癌 非小细胞肺 组织多肽特异性抗原 肿瘤标志物 

分 类 号：R734.2[医药卫生—肿瘤]