雷贝拉唑治疗反流性食管炎和非糜烂性胃食管反流病反应时间的研究  

A Study of Reaction Time of Rabeprazole Treatment on Reflux Esophagitis Symptom and Non-erosive Gastro-oesophageal Reflux Disease

作　　者：姚萍[1] 董文珠[1] 王群英[1] 钟慧闽[1] 宋健[1] 

机构地区：[1]中国人民解放军第401医院消化科,山东青岛266071

出　　处：《中国慢性病预防与控制》2010年第2期168-169,180,共3页Chinese Journal of Prevention and Control of Chronic Diseases

摘　　要：目的探讨雷贝拉唑治疗反流性食管炎(RE)和非糜烂性胃食管反流病(NERD)的反应时间。方法对92例具有反酸、烧心、胸骨后疼痛、反食等典型反流症状患者,经填写反流性疾病问卷和胃镜检查,确定NERD组36例、RE(A-B)组42例、RE(C-D)组14例,雷贝拉唑10mg2次/d口服。服药1周、2周随访,观察症状积分、症状发作频率改善情况,以症状积分减少1/2的时间点(d)作为对雷贝拉唑治疗的反应时间。结果治疗后第一周NERD组症状积分(8.56±2.41)分,RE(A-B)组(4.66±2.02)分,RE(C-D)组(5.76±1.98)分,NERD组与RE(A-B)组、RE(C-D)组比较,差别均有统计学意义(P<0.001);治疗后第二周NERD组(6.38±2.30)分,RE(A-B)组(3.71±1.64)分,RE(C-D)组(3.11±2.55)分,NERD组与RE(A-B)组、(C-D)组比较,差别有统计学意义(P<0.001);NERD组治疗后第一周总有效率为58.3%,RE(A-B)组为83.3%(P<0.01);治疗后第二周NERD组总有效率为66.7%,RE(A-B)组为88.1%(P<0.05)。NERD组对雷贝拉唑的反应时间为(6.54±2.34)d,RE(A-B)组为(2.13±1.38)d,RE(C-D)组为(3.33±1.67)d,RE两组分别与NERD组比较,差别有统计学意义(P<0.001)。结论反流性食管炎、非糜烂性胃食管反流病对雷贝拉唑治疗的症状改善情况、反应时间不同,以反流性食管炎症状改善快、反应时间短,而非糜烂性胃食管反流病症状改善慢、反应时间长。Objective To study the efficacy and the reaction time of Rabeprazole treatment on RE （reflux Esophagitis symptom） and NERD （non-erosive gastro-oesophageal reflux disease）. Methods Among 92 cases with symptoms of acid reflux, heartburn, retrosternal pain, regurgitation and other typical regurgitation, 36 cases were diagnosed as NERD, 42 cases as RE （A- B）, 14 cases as RE （C-D） by questionnaire and gastroscope. 10 mg Rabeprazole was taken orally twice a day. a follow-up survey was conducted at the end of the first and second week after taking the medicine and the symptom improvement score was observed; the treatment reaction time was determined by means of symptom score reduction of 1/2 time point （day）. Results At the first week of treatment, the symptom scores in NERD group was 8.56±2.41, RE （A-B） group 4166±2.02, RE （C-D）group 5.76±1.98, respectively （P〈0.001）. At the second week after treatment, the symptom score was 6.38±2.30 in NERD group, 3.71±1.64 in RE （A-B） group, and 3.11 ±2.55 in RE （C-D）group （P〈0.001）. The total efficacy rate of symptom improvement after the first week treatment was 58.3% in NERD group and 83.3% in RE （A-B） group （P〈0.01）, and after the second week treatment was 66.7% and 88.1%, respectively （P〈0.05）. There were no difference between group RE （C-D）and group NERD in the first and second weeks （P〉0.05）. The reaction time （day） to Rabeprazole treatment for each group was 6.54±2.34 in NERD group, 2.13±1.38 in RE （A-B） group, and 3.33±1.67 in RE （C-D）. Conclusion The improvement and reaction time to Rabesprazole treatment are different in RE and NERD group, i.e., it has a fast improvement and takes shorter reaction time for reflux esophagitis symptom （RE）, but it is slow and takes longer reaction time for non-erosive gastro-oesophageal reflux disease （NERD）.

关 键 词：雷贝拉唑 反流性食管炎 非糜烂性胃食管反流病 症状积分 总有效率 反映时间 

分 类 号：R571[医药卫生—消化系统]