洛阳地区20年间食管病变的变化分析  

Analysis of changes of esophagus lesions in Luoyang area in 20 years

作　　者：冯笑山[1] 侯建峰[1] 董彩红[2] 高社干[1] 王公平[1] 张广平[1] 郝曙光[1] 周博[1] 陈强[1] 茹艺[1] 

机构地区：[1]河南科技大学第一附属医院肿瘤科,洛阳471003 [2]河南科技大学第一附属医院胃镜科,洛阳471003

出　　处：《中国肿瘤临床与康复》2010年第2期97-99,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨洛阳地区食管癌、食管黏膜上皮不典型增生和食管炎三类食管病变的发病现状及发生规律。方法对20年间经胃镜检查并经病理确诊的10 646例三类食管病变,依据其类别、年龄、性别、城乡差异进行前、后十年对比以及性别年龄段分布,分析其发病过程及流行病学现状。结果后十年与前十年对比,三类病变绝对数值分别增加1258例、297例和279例;发病年龄分别延迟4.05年、4.95年和3.24年;性别构成为男性多于女性,与前十年没有明显变化(P>0.05);城乡构成为农村多于城市,食管炎和食管癌城乡构成较前十年没有明显变化(P>0.05),但食管黏膜上皮不典型增生农村发病比例较前十年显著增多(P<0.05);食管癌和食管黏膜上皮不典型增生男女发病的高峰年龄在60～69岁,而食管炎男女发病的高峰年龄在50～59岁。结论提示食管癌仍是洛阳地区最常见的食管疾病,而食管癌的发生是一个渐进的过程,其发生规律与食管炎和食管黏膜上皮不典型增生密切相关。Objective To investigate the present situation and regularity of morbidity of esophageal cancer,esophageal epithelial dysplasia and esophagitis in Luoyang area.Methods 10646 cases of esophageal lesions diagnosed by gastroscopy and the pathological examination in 20 years were copared between first 10 and second 10 years according to the three categories,age,gender,urban and rural differences and the pathogenesis and epidemiological status were analyzed according to the comparison,gender and age distribution.Results Compared with the first ten years in second ten years,the absolute number of three lesions increased by 1258,297and 279 cases,and the age of disease onset delayed by 4.05,4.95,3.24 years respectively.Gender difference i.e.men more than women,did not change significantly（P0.05）.For the urban and rural cases,rural was more than urban,and esophageal cancer and esophagitis did not change significantly（P0.05）,but the esophageal epithelial dysplasia in rural area increased significantly in second ten years compared with a decade before（P0.05）.Morbidity of esophageal cancer and esophageal epithelial dysplasia in men and women peaked at age of 60 to 69 years,and the morbidity of esophagitis in men and women peaked at 50 to 59 years old.Conclusion Esophageal cancer is still the most common esophageal disease in Luoyang,and esophageal cancer is a gradual process,its occurrence regularity is closely related with esophagitis and esophageal epithelial dysplasia.

关 键 词：食管炎 食管黏膜上皮不典型增生 食管癌 流行病学 

分 类 号：R571[医药卫生—消化系统]