宫颈癌术前介入化疗栓塞的临床应用  

The preoperative interventional chemoembolization for the treatment of cervical cancer: its clinical application

作　　者：张帆 许哲 

机构地区：[1]呼伦贝尔市人民医院介入科,内蒙古海拉尔021008

出　　处：《中国肿瘤临床与康复》2010年第2期131-133,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨Ⅰb～Ⅱb期宫颈癌术前介入化疗栓塞的临床疗效及病理学改变。方法对2005年1月至2009年1月在我院就诊的55例宫颈癌患者实施术前动脉介入化疗,抗癌药物为顺铂、表阿霉素、5-Fu,灌注化疗后用明胶海绵颗粒栓塞肿瘤供血动脉。结果55例宫颈癌患者经1～2次术前介入化疗后顺利手术切除,术后标本病理切片中可见大量坏死组织及淋巴细胞浸润,其中组织学完全缓解8例。结论宫颈癌术前介入化疗栓塞可有效缩小肿瘤体积,减少术中出血,部分患者可达到组织学完全缓解的效果。Objective To assess the effectiveness of preoperative interventional chmoembolization in the treatment of cervical cancer and to observe the pathological changes of the tumor after the procedure.Methods During the period of Jan.2005-Jan.2009,preoperative interventional chemoembolization was performed in 55 patients with cervical cancer.The antineoplastic drugs included cisplatin,epirubicin and 5-Fu.In all patients,interventional arterial infusion chemotherapy was carried out before the embolization of bilateral tumor-feeding arteries with gelfoam was made.Results Fifty-five patients underwent radical resection surgery after receiving 1 or 2 times of chemoembolization.In postoperative pathological examination,massive necrosis and lymphocytic infiltration were found within the tumor and histological complete remisson（HCR） was seen in 8 patients.Conclusion For the treatment of cervical cancer,the preoperative interventional chemoembolization can effectively decrease the tumor size and reduce blood loss during operation,moreover,even HcR can be obtained in some patients.

关 键 词：宫颈肿瘤 介入性化疗 病理评价 

分 类 号：R737.33[医药卫生—肿瘤] R730.53[医药卫生—临床医学]