微米大黄炭对乙酸溃疡大鼠血浆PGE_2含量的影响  

Effects of Micron Rhubarb Charcoal on Plasma PGE_2 Concentration in Rat of Acetic Acid Ulcer

作　　者：张书[1] 时昭红[1] 冯云霞[1] 

机构地区：[1]武汉市第一医院消化内科,湖北武汉430022

出　　处：《成都中医药大学学报》2010年第1期63-64,共2页Journal of Chengdu University of Traditional Chinese Medicine

基　　金：武汉市卫生局科研基金项目(编号:武卫[2003]228号)

摘　　要：目的:观察微米大黄炭对乙酸溃疡大鼠血浆PGE2含量的影响。方法:用冰醋酸制备大鼠慢性胃溃疡模型,随机分为4组(空白对照组、模型组、微米大黄炭组和雷尼替丁组),分别灌服生理盐水、促愈颗粒和雷尼替丁。心脏穿刺取血后用放射免疫法检测血浆PGE2含量。结果:与模型组相比,微米大黄炭组和雷尼替丁组血浆PGE2含量均明显提高(P<0.05,P<0.01);微米大黄炭组与雷尼替丁比无显著差异(P>0.05)。结论:微米大黄炭可显著促进胃溃疡大鼠上皮细胞合成和分泌PGE2,从而增强胃黏膜防御功能。Objective：To study the effects of micron rhubarb charcoal on the levels of plasma PGE2 in rats of acetic acid ulcer.Methods： The model rats of chronic gastric ulcer were prepared with acetic acid and randomly divided into A、B、C and D group,which were given normal saline,micron rhubarb charcoal and ranitidine respectively.Before of cardiac puncture the levels of plasma PGE2 was detected by radioimmunoassay.Results： Compared with model group,micron carbon rhubarb group and the ranitidine plasma PGE2 levels were markedly improved（P0.05,P0.01）,but compared with C and D groups showed no significant difference.Rhubarb-micron carbon can significantly promote the gastric ulcer in rat epithelial cells synthesize and secrete PGE2,enhance the function of gastric mucosa defense.Conclusion： Rhubarb-micron carbon can significantly promote the gastric ulcer in rat epithelial cells synthesize and secrete PGE2,thereby enhancing the gastric mucosal defensive function.

关 键 词：微米大黄炭 胃溃疡 PGE2 

分 类 号：R285.5[医药卫生—中药学] R573.1[医药卫生—中医学]