急性脑梗死血清肌钙蛋白-T升高的临床观察  

On the serum concentrations of troponin T in acute ischemic stroke

作　　者：黄立[1] 龚细礼[1] 杜芬[1] 杜小平[2] 

机构地区：[1]湖南师范大学附属湘东医院神经内科,湖南醴陵412200 [2]中南大学湘雅医院神经内科,湖南长沙410000

出　　处：《现代生物医学进展》2010年第4期709-711,共3页Progress in Modern Biomedicine

摘　　要：目的:探讨急性脑梗死患者血清肌钙蛋白水平升高与梗死严重程度、梗死部位和预后的关系。方法:247例急性脑梗死患者,在住院的第一天内完成12导联心电图及血清肌钙蛋白-T(cTnT)水平的检查。以0.5ng/ml为界,将患者分为cTnT水平升高组和cTnT水平正常组。结果:26例(10.5%)血清cTnT水平升高。与cTnT水平正常组相比,cTnT水平升高组患者入院时NIHSS评分更严重,岛叶受累的发生率更高,预后较差,异常心电图发生率较高。结论:血清cTnT水平升高的急性脑梗死患者梗死更严重,预后较差,这些患者大多岛叶受累和ECG异常。Objective： To identify the relationships between elevated cTnT and stroke severity, location, and prognosis. Methods： Cardiac Troponin T （cTnT） concentrations and 12-lead electrocardiograms were obtained during the first day of admission in 247 patients with acute ischemic stroke but without overt ischemic heart disease. The cut-off value for elevated serum cTnT was set at 0.5ng/ml. Patients were divided into 2 groups： an elevated cTnT group and a normal cTnT group. Results： Serum cTnT was elevated in 10.5% of cases, with elevated cTnT associated with greater stroke severity, as assessed by the NIHSS score. Insular-lobe involvement and abnormalities of ECG were more common in patients with elevated cTnT than in the normal cTnT group. Short-term prognosis was more unfavorable in the elevated cTnT group than in the normal cTnT group. Conclusions： Elevated cTnT in acute ischemic stroke was associated with severe neurological deficits at stroke onset and damages to the insular lobe. The outcome of acute ischemic stroke was worse for patients with elevated cTnT than for those with normal cTnT.

关 键 词：肌钙蛋白 脑梗死 预后 

分 类 号：R743[医药卫生—神经病学与精神病学]