甲状腺癌患者血清促甲状腺激素和甲状腺激素表达水平及临床意义  

The expression and significance of hormothyrin and thyroid hormone in thyroid cancer

作　　者：桑伟[1] 田亮[1] 郭长军[1] 蒋金芳[1] 商晓青[1] 李锋[1] 赵瑾[1] 

机构地区：[1]石河子大学医学院病理学教研室,新疆石河子832002

出　　处：《现代生物医学进展》2010年第4期715-717,共3页Progress in Modern Biomedicine

摘　　要：目的:探讨甲状腺癌患者血清促甲状腺激素和甲状腺激素表达水平及临床意义。方法:应用电化学发光方法检测甲状腺癌组、甲状腺良性病变组和正常对照组血清促甲状腺激素(TSH)和甲状腺激素(TT3、FT3、TT4、FT4)水平。结果:①血清TSH在三组中比较有统计学意义(P〈0.001),甲状腺癌组血清TSH水平(3.56±0.93ulU/ml)明显高于甲状腺良性病变组(2.82±0.70ulU/ml)和正常对照组(2.04±0.56ulU/ml);TSH与肿瘤病理分期和肿瘤大小呈正相关(P<0.05)。②血清FT3、FT4水平在三组中有统计学意义(均P〈0.001),甲状腺癌组FT3、FT4水平处于较低水平,二者均明显低于甲状腺良性病变组和正常对照组(P<0.001);FT3与肿瘤病理分期和淋巴结转移呈负相关(P<0.05)。③TT3和TT4水平在三组之间比较均无统计学意义(P>0.05)。结论:高水平TSH可增加甲癌复发的危险性。低甲状腺激素水平在甲状腺癌形成中可能起到一定的作用,因此可以将其作为预测甲癌复发的重要指标之一。Objective： To observe the expression and significance of hormothyrin and thyroid hormone in thyroid cancer. Methods： The expression of hormothyrin（TSH）and thyroid hormone（TT3,FT3,TT4,FT4）was assayed by electrochemiluminescence in thyroid cancer ,benign lesion and normal subjects. Results： ①The comparison of the TSH lever in three groups is sense, and the TSH lever is significantly higher in thyroid cancer （3.56±0.93 ulU/ml）than in that benign lesion （2.82±0.70 ulU/ml）and normal subjects （2.04±0.56 ulU/ml）（P〈0.001）, the TSH lever is positive correlation with tumor pathology staging and tumor size. ②The comparison of the FT3 and FT4 lever in three groups is sense （P〈0.001）,they are both lower in thyroid cancer than in that benign lesion and normal subjects（P〈0.001）, the FT3 lever is inverse correlation with tumor pathology staging and lymphoid node metabasis. ③The lever of TT3 and TT4 are nonsense between three groups （P〉0.05）. Conclusions： High TSH lever could increase recurrence rates. Low thyroid hormone lever may play a certain role in thyroid cancer, so thyroid hormone can be as one of predictors to evaluate thyroid cancer recurrence.

关 键 词：促甲状腺激素 甲状腺激素 甲状腺癌 

分 类 号：R736.1[医药卫生—肿瘤]