原发性醛固酮增多症与睡眠呼吸暂停关系的研究现状  

Primary Aldosteronism and Sleep Apnea Syndrome

作　　者：张福春[1] 严治涛[1] 杨晶晶[1] 李南方 

机构地区：[1]石河子大学,新疆石河子830001 [2]自治区人民医院,新疆乌鲁木齐830000

出　　处：《现代生物医学进展》2010年第4期794-796,共3页Progress in Modern Biomedicine

摘　　要：近年来,随着筛查技术的提高,原发性醛固酮增多症的检出大大提高,并且在抵抗性高血压中的检出也比普通人群中高出很多,原发性醛固酮增多症的发病率从不到1%增加到5%-15%。研究发现,在高危险的睡眠呼吸暂停低通气综合症症状的患者中,原发性醛固酮增多症的检出高于低危险的睡眠呼吸暂停低通气综合症症状组。由此我们了解到睡眠呼吸暂停低通气综合症与原发性醛固酮增多症之间存在着某种必然的联系,其病理生理的联系,以及都可以导致继发性高血压和严重的心、脑并发症等。原发性醛固酮增多症其超生理的醛固酮或是睡眠呼吸暂停低通气综合症患者中低氧和高碳酸血症引起的醛固酮的增高都可以导致高血压及高血压的心脏,肾脏等靶器官的损害。然而,睡眠呼吸暂停低通气综合症与原发性醛固酮增多症之间的关系还不是很清楚,需要我们进一步的研究。Recently, as the improvement of screening technology ,there is the high prevence of primary hyperaldosteronism .Besides, it is presented that It is an higher prevence of PA with resistant hypertension than essential hypertension ,which is from less than 1% to 5%-15% . PA was more prevalent in subjects at high risk compared to subjects at low risk symptom of OSA .So there would be some relationships between the PA and OSA ,such as physiopathologic and both leading to resistant hypertension、sever heart and kidney complication. Aldosterone which is bring from PA or hypoxia and high carbonation of OSA can bring about resistant hypertension 、sever heart and kidney complication. However ,the relationship between PA and OSA are not clear ,we should research deeply.

关 键 词：原发性醛固酮增多症 睡眠呼吸暂停低通气综合症 高血压 醛固酮 

分 类 号：R-332[医药卫生] R322.61