肝硬化患者低钠血症及低钙血症的临床研究  

The clinical analysis of hyponatremia and hypocalcemia in hepatic cirrhosis patients

作　　者：刘明娜[1] 高善玲[1] 赵晶[1] 裴凤华[1] 

机构地区：[1]哈尔滨医科大学附属二院消化内科,150086

出　　处：《齐齐哈尔医学院学报》2010年第4期511-513,共3页Journal of Qiqihar Medical University

摘　　要：目的探讨肝硬化伴低钠血症及低钙血症患者血清钠和血清钙的变化规律及临床意义。方法测定肝硬化患者(104例)的血清钠、血清钙的水平,与正常对照组(42例)比较。结果肝硬化组的血清钠、血清钙水平(分别为131.85±4.39mmol/L,1.99±0.11mmol/L)明显低于对照组(分别为140.31±4.12mmol/L,2.38±0.14mmol/L),差异有显著性(P<0.01)。肝硬化患者按肝功能Child-Pugh分级法分为A、B、C级3个亚组,C级组患者的血清钠及血清钙浓度(分别为129.60±3.08mmol/L,1.90±0.12mmol/L)明显低于A级组(分别为134.87±4.76mmol/L,2.13±0.08mmol/L)和B级组(分别为131.76±4.21mmol/L,1.98±0.14mmol/L),差异有显著性(P<0.01)。结论低钠血症和低钙血症是肝硬化的常见并发症之一,其血清钠和血清钙水平随肝功能级别的递增而逐渐降低。加强对肝硬化患者血清钠和血清钙的监测,可及时诊断和治疗肝硬化患者并发的低钠和低钙血症。Objective To study the changes of blood sodium ion and calcium ion level in cirrhotic patients. Methods Measurement of the blood sodium ion and calcium ion level in cirrhotic patients was finished,and compared with normal control group. Results The blood sodium ion and calcium ion concentration in cirrhotic group（131.85±4.39mmol/L,1.99±0.11mmol/L） was lower than control group（140.31±4.12mmol/L,2.38±0.14mmol/L）,the difference was statistically significant（P〈0.01）. The blood sodium and calcium concentration were fractionated into class A,B,C with Child-Pugh grade in cirrhotic group. The blood sodium ion and calcium ion concentration in class C （129.60±3.08mmol/L,1.90±0.12mmol/L）was lower than class A（134.87±4.76mmol/L,2.13±0.08mmol/L）and B（131.76±4.21mmol/L,1.98±0.14mmol/L）,the difference was statistically significant（P〈0.01）. Conclusions Hyponatremia and hypocalcemia were two common complications in hepatic cirrhosis,and the blood sodium ion and calcium ion level were gradually lower with the decrease of liver function. We should enhance the monitoring of the blood sodium ion and calcium ion level,and then hyponatremia and hypocalcemia in cirrhotic patient can be diagnosed and cured in time.

关 键 词：肝硬化 低钠血症 低钙血症 

分 类 号：R575.2[医药卫生—消化系统]