毛细管气相色谱法测定头孢西丁钠中有机溶剂的残留量  

Determination of Residual Organic Solvents in Cefoxitinsodium by Gas Chromatography

作　　者：朱庆珍[1] 

机构地区：[1]苏州农业职业技术学院,江苏苏州215008

出　　处：《解放军药学学报》2010年第2期131-132,共2页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：目的建立毛细管气相色谱法测定头孢西丁钠中的乙醇、丙酮、乙酸乙酯的含量。方法采用HP-5毛细管柱(30m×0.53mm,1.5μm);柱温恒温;FID检测器;载气N2。结果各溶剂的线性关系良好(r均在0.99以上),平均回收率为98.6%～101.7%。结论毛细管气相色谱法测定头孢西丁钠中的残留溶剂,方法简便,结果准确。Objective To establish a capillary gas chromatography method for the determination of residual organic solvents-alcohol, acetone, ethyl acetate in CefoxitinSodium. Methods An HP-5 column（30 m×0.53 mm,1.5 μm） was used with constant column temperature control;FID and the carrier gas N2 were used. Results The calibration curves of three solvents were linear（r〉0.99）. The average recovery was 98.6%-101.7%. Conclusion This simple and accurate method can be used to detect the residual organic solvents in CefoxitinSodium.

关 键 词：头孢西丁钠 有机溶剂残留量 气相色谱法 

分 类 号：R927.2[医药卫生—药学]