暂时脑动脉阻断、系统降压和升压安全性的实验研究  

Experimental Study on the Safety Limits of Temporary Arterial Occulsion and/or Controlled Hypotension of Hypertension

作　　者：梁勇[1] 周良辅[1] 毛颖[1] 郭欢欢[1] 黄峰平[1] 

机构地区：[1]上海医科大学附属华山医院神经外科,200040

出　　处：《中国临床神经科学》1998年第4期204-206,共3页Chinese Journal of Clinical Neurosciences

摘　　要：对动脉阻断和(或)系统降压、升压不同措施导致脑缺血的可能性进行实验研究.结果:各组在海马下脚CAl区及额顶叶脑皮层Ⅲ～Ⅳ层的神经细胞内抗微管相关蛋白2(MAP2)含量均有不同程度的下降,阻断一侧颈内动脉联合系统升压组MAP2含量减少的程度最小(P<0.05).提示动脉阻断联合系统升压是一种相对安全措施.To experimentally investigate the safety limits of temporary arterial occlusion and/or controlled hypotension or hypertension using gerbil forebrain ischemia model. Loss of immunohistochemical reaction for microtube-associated protein 2 (MAP2) in the dendrites of neurons became apparent in the subiculum-CA1 region and in the layer III / IV of the cerebral cortex in all groups. The animals in the group with one lateral CCA occlusion coupled with hypertension showed a minimum decrease of MAP2 content (P<0. 05). The results suggest the arterial occlusion combined with hypertension is a relatively safe method.

关 键 词：动脉阻断 系统降压 系统升压 脑缺血 安全性 

分 类 号：R743.310.5[医药卫生—神经病学与精神病学]