卵巢恶性肿瘤组织中HLA-G、HLA-E的表达及意义  

Expression and significance of HLA-G and HLA-E in the tissue of ovarian malignant tumor

作　　者：王建英[1] 许茜[1] 吴淑娟[1] 李勇[1] 程建新[1] 

机构地区：[1]河北医科大学第四医院,石家庄050011

出　　处：《山东医药》2010年第15期1-3,共3页Shandong Medical Journal

基　　金：河北省科学技术研究与发展计划项目(08276101D-78)

摘　　要：目的探讨人白细胞抗原(HLA)在卵巢恶性肿瘤发生、发展中的作用。方法采用RT-PCR和流式细胞分析技术检测60份卵巢恶性肿瘤组织(恶性组)、30份卵巢良性肿瘤组织(良性组)和10份正常卵巢组织(对照组)标本中HLA-G、HLA-E的表达。结果恶性组HLA-G、HLA-E阳性表达率显著高于良性组与对照组(P均<0.05);HLA-G、HLA-E表达与肿瘤组织类型无关,与临床分期、病理分级显著相关,临床期别越晚、组织分化越差,抗原表达水平越高。结论HLA-G、HLA-E参与了卵巢恶性肿瘤的发生、发展过程,可能机制为癌细胞产生免疫耐受,逃逸宿主的免疫监视。Objective To investigate the significance of human leukocyte antigen （HLA） in the occurrence and development of ovarian malignant neoplasm. Methods RT-PCR and flow cytometry methods were performed to examine the expression of HLA-G and HLA-E in 60 tissues of ovarian malignant neoplasm（malignant group） ,30 tissues of benign ovarian （benign group ）and 10 tissues of normal ovarian（control group）. Results The positive rates of HLA-G and HLA-E in malignant group were higher than those in the benign group and control group （ both P 〈 0.05）. There were no statistical differences of the HLA-G and HLA-E expression among different histological typies, but the expression levels of HLA-G and HLA-E were increasing according with the clinical stage and differentation level. Conclusion HLA-G and HLA-E might participate in the occurrence and development of ovarian malignant neoplasm, possible mechanism relates to the immune escape of cancer cell.

关 键 词：卵巢肿瘤 人白细胞抗原-G 人白细胞抗原-E 免疫逃逸 

分 类 号：R737.3[医药卫生—肿瘤]