艾迪注射液联合5-氟尿嘧啶加顺铂化疗方案治疗中晚期肝癌  

Aidi injection combined with 5-fluorouracil and cisplatinum for advanced liver cancer

作　　者：冯献明[1] 付方现[1] 刘俊叶[1] 韩文清[1] 李永峰[1] 

机构地区：[1]林州市肿瘤医院肿瘤科,河南林州456550

出　　处：《新乡医学院学报》2010年第3期273-275,共3页Journal of Xinxiang Medical University

摘　　要：目的观察艾迪注射液联合5-氟尿嘧啶加顺铂(FP方案)治疗中晚期肝癌的疗效。方法晚期原发性肝癌患者70例分为2组,对照组应用FP方案化疗,观察组在应用FP方案化疗同时,加用艾迪注射液,采用艾迪注射液50 mL+生理盐水500 mL静脉滴注,每日1次,21 d为1个周期,2个周期为1疗程。2组患者均接受2个疗程的治疗。结果观察组缓解率高于对照组,恶化率低于对照组(P<0.05);治疗后2组生活质量都有不同程度的提高,观察组患者生活质量提高稳定率高于对照组(P<0.05);与治疗前比较,化疗2个疗程后,观察组外周血白细胞无明显降低(P>0.05),而对照组血白细胞明显降低(P<0.05)。结论艾迪注射液联合FP方案治疗中晚期肝癌疗效显著。Objective To observe the curative effect of Aidi injection combined with 5-fluorouracil and cisplatinum（FP） for advanced liver cancer. Methods Seventy patients with advanced primary liver cancer were divided into two groups. The pa- tients in control group were given 5-fluorouracil and cisplatinum. Based on this, the observation group was given Aidi injection （50 mL Aidi injection ＋ 500 mL normal saline were given by intravenous infusion,once-daily,21 days for a cycle, two cycles of a course of treatment）. All patients were treated for two courses of treatment. Results Compared with control group,the ease rate was significantly higher and the rate of deterioration was significantly lower in observation group（ P 〈 0.05 ） ;The quality of life in two groups have different degrees of increase after treatment, and the stability rates plus improving rates was significantly higher in observation group than that in control group （P 〈 0.05 ） ;Compared with before treatment, there was no significantly de- crease of peripheral white blood cells in observation group after treatment （ P 〉 0.05 ） ; After two courses of chemotherapy treatment, the white blood cells levels were lower than before treatment （ P 〈 0.05 ）. Conclusion Aidi injection combined with FP in treatment of advanced liver cancer has a significant effect.

关 键 词：原发性肝癌 艾迪注射液 5-氟尿嘧啶 顺铂 化疗 

分 类 号：R735.7[医药卫生—肿瘤]