乳腺癌中IMP3表达及其与临床病理特征的关系  

IMP3 expression and its relationship with clinicopathological characteristics in breast carcinoma

作　　者：苏鹏[1] 杨其峰[2] 周志强[1] 王妍[1] 刘文君[1] 张庆慧[1] 

机构地区：[1]山东大学齐鲁医院病理科,济南250012 [2]山东大学齐鲁医院乳腺外科,济南250012

出　　处：《临床与实验病理学杂志》2010年第1期18-21,共4页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的研究乳腺癌中IMP3的表达及其与临床病理特征之间的关系。方法利用组织芯片技术和免疫组织化学EliVi-sion两步法检测214例乳腺癌标本中IMP3的表达。结果214例乳腺浸润性导管癌中,IMP3阳性表达31例(14.49%)。乳腺癌IMP3的阳性表达与乳腺癌的组织学级别(P=0.005)、Ki-67增殖指数(P=0.033)及三阴性表型(P<0.001)密切相关。IMP3的表达与病人年龄、肿瘤最大直径、淋巴结转移数量、pTNM分期和p53表达状况均无关(P>0.05)。结论IMP3表达与乳腺癌组织级别高、Ki-67增殖指数高以及在三阴性亚组表达高相关,预示IMP3与乳腺癌的进展和恶性度相关,并可能作为三阴性乳腺癌的一个辅助诊断指标。Purpose To investigate the expression of IMP3 and its relationship with clinicopathological characteristics in breast cancer.Methods By the tissue microarray technique and immunohistochemical EliVision two-step method,expression of IMP3 was detected in 214 cases of breast carcinoma.Results Of the 214 breast cancer cases,IMP3 expression was seen in 31（14.49%）.IMP3 expression in the tumor cells was positively correlated with histological grade （P=0.005）,proliferative index labeled by Ki-67 （P=0.033） and triple negative phenotype （P〈0.001）.There were no associations between IMP3 expression and age,tumor size,lymph node metastases,pTNM stage or p53 expression （P〉0.05）.Conclusions Expression of IMP3 is correlated with higher histologic grade,higher proliferative activity and triple negative breast carcinoma.Our findings indicate that IMP3 plays an important role in breast cancer progression,and IMP3 could be an adjuvant diagnostic marker in triple negative breast carcinoma.

关 键 词：乳腺肿瘤 IMP3 组织芯片 三阴性 

分 类 号：R737.9[医药卫生—肿瘤]