50例晚期胰腺癌三维适形放疗的近期疗效分析  

Analysis of short-term efficacy of 3D conformal radiotherapy for late-stage pancreatic cancer

作　　者：王凤玮[1] 尹晓东[1] 刘兴强[2] 王新卓[1] 张龙[1] 周培[1] 张明增[1] 王建华[2] 江涛[2] 

机构地区：[1]天津市人民医院放疗科,300130 [2]天津市人民医院消化外科,300130

出　　处：《中华肝胆外科杂志》2010年第3期173-175,共3页Chinese Journal of Hepatobiliary Surgery

摘　　要：目的分析三维适形放疗治疗晚期胰腺癌的疗效及相关预后因素。方法50例不能手术的晚期胰腺痛病人，采用常规分割的三维适形放疗；其巾14例采用姑息性放疗（A组），给予10．8～56Gy；27例采用单一三维适形放疗（B组），剂量范围为8～60．5Gy；9例采用同步放化疗的方法（C组），剂量范围为10～64Gy。同步放化疗中化疗采用吉西他滨（200～600mg/m^2，1次／周）。结果随访时间为3～35个月，死亡43例，死亡原因主要为肝脏和（或）腹腔内的广泛转移、恶液质、继发感染和出血。存活7例中3例为同步放化疗，3例为单一放疗，1例为姑息治疗。A组存活1人，放疗后局部症状缓解率46％（6／]3），平均生存时间5．07个月；其中放疗剂量小于45Gy的病人有10例，平均存活时间为4．33个月；放疗剂量≥45Gy者3例，平均存活时间为7．33个月。B组存活3例，治疗后疼痛缓解率为81％（22／27），平均存活6．65个月，其中放疗剂量小于45Gy的有11例，平均存活时间为4．36个月；放疗剂量≥45Gy者16例，平均存活时间为8．33个月。C组存活3例，治疗后疼痛缓解率为89％（8／9），放疗后平均存活9．89个月，其中放疗剂量小于45Gy的有1例，存活时间为3个月；放疗剂量≥45Gy者8例，平均存活时间为10．73个月。结论三维适形放疗对晚期胰腺癌有姑息治疗的作用，疗效与治疗方式的选择、放疗剂量、病变累及范围和病人一般状态密切相关。对于部分晚期胰腺癌病人，采用积极同步放化三维适形放疗可获得较长的生存时间。Objective To investigate the efficacy of 3D conformal radiotherapy for late-stage pancreatic cancer and determine relavent prognostic factors. Methods Fifty patients with advanced pancreatic cancer were divided into 3 groups according to treatment planning： palliative radiotherapy （group A） at 10.8-56 Gy, radiotherapy alone （group B） at 8-60.5 Gy and concurrent ehemoradiotherapy （group C） at 10 64 Gy. All patients received 3D-conformal radiotherapy, and smaller multiple ports were used for palliative treatment whereas large fields including pancreatic tumors and adjacent lymph node drainage system were adopted in the beginning of radiotherapy. Concurrent chemotherapy with gemcitabine （200 600 mg/m^2） alone was used with weekly protocol. Results The duration of follow up was 3 3.5 months. Forty three patients died during the follow-up for multiple metastasis, deteriation, secondary infection and hemorrhage. Among the seven surviving patients, 3 received concurrent radiotherapy, 3 radiotherapy alone and 1 palliative radiotherapy. Only 1 patient was alive in group A. However, the symtoms were relieved in 46% of the patients. The median survival time was 5.07 months whereas it was 4.33 months for patients received less than 45 Gy and 7.33 months for patients received 45 Gy or more. Three patients were alive in group B and the symptoms were relieved in 81% of the patients. The median survival time was 6.65 months whereas it was 4.36 months for patients received less than 45 Gy and 8.33 months for patients received 45 Gy or more. Three patients were a- live in group C and the symptoms were relieved in 89% of the patients. The median survival time was 9.89 months. One patient survived for 3 months after 8 Gy irradiation. The median survival time was 10.73 months for patients received 45 Gy or more. Conclusion 3D-conformal radiotherapy is safe and effective in treatment of advanced pancreatic cancer. The symptom relieving rate and median survival time seem to be related to patient＇s status, extent of

关 键 词：胰腺肿瘤 同步放化疗 三维适形放疗 

分 类 号：R735.9[医药卫生—肿瘤]